Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 6/20 | 0.79 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.49 |
| ▸ | MAPT | P10636 | 5/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | CDC7 | O00311 | 1/20 | 0.46 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.46 |
| ▸ | DHODH | Q02127 | 4/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29831789 | 0.92 | PDE5A (0.79) | PDE5AKDM4EMAPTALDH1A1LMNA | |
| SCHEMBL291110 | 0.92 | PDE5A (0.79) | PDE5AKDM4EMAPTALDH1A1LMNA | |
| SCHEMBL29831900 | 0.91 | PDE5A (0.75) | PDE5AKDM4EMAPTALDH1A1LMNA | |
| SCHEMBL290429 | 0.91 | PDE5A (0.75) | PDE5AKDM4EMAPTALDH1A1LMNA | |
| SCHEMBL292060 | 0.91 | PDE5A (0.77) | PDE5AKDM4EMAPTALDH1A1LMNA | |
| SCHEMBL291286 | 0.91 | PDE5A (0.77) | PDE5AKDM4EMAPTALDH1A1LMNA | |
| SCHEMBL290089 | 0.90 | PDE5A (0.76) | PDE5AKDM4EMAPTALDH1A1LMNA | |
| SCHEMBL29831949 | 0.90 | PDE5A (0.76) | PDE5AKDM4EMAPTALDH1A1LMNA | |
| SCHEMBL291321 | 0.90 | PDE5A (0.76) | PDE5AKDM4EMAPTALDH1A1LMNA | |
| SCHEMBL2680309 | 0.90 | PDE5A (0.76) | PDE5AKDM4EMAPTALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7087614-B2 | Pyrimidine inhibitors of phosphodiesterase (PDE) 7 | BRISTOL-MYERS SQUIBB CO. (US) | 2006-08-08 | — | — | US | disclosed |