Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 3/20 | 0.49 |
| ▸ | NAPEPLD | Q6IQ20 | 5/20 | 0.43 |
| ▸ | PIK3CB | P42338 | 6/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | CRHBP | P24387 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.39 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.38 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL291617 | 0.91 | PDE5A (0.59) | PDE5A | |
| SCHEMBL291292 | 0.90 | PDE5A (0.54) | PDE5ANAPEPLD | |
| SCHEMBL291289 | 0.89 | PDE5A (0.48) | PDE5ANAPEPLD | |
| SCHEMBL300239 | 0.89 | PDE5A (0.49) | PDE5ANAPEPLD | |
| SCHEMBL289912 | 0.85 | PDE5A (0.46) | PDE5A | |
| SCHEMBL290607 | 0.85 | PDE5A (0.44) | PDE5A | |
| SCHEMBL2696718 | 0.84 | PDE5A (0.52) | PDE5APKM | |
| SCHEMBL291755 | 0.83 | PDE5A (0.56) | PDE5ANAPEPLD | |
| SCHEMBL290600 | 0.83 | PDE5A (0.64) | PDE5ANAPEPLDPKM | |
| SCHEMBL26647589 | 0.83 | PIK3CA (0.51) | PDE5APIK3CBPIK3CAPIK3CDTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7087614-B2 | Pyrimidine inhibitors of phosphodiesterase (PDE) 7 | BRISTOL-MYERS SQUIBB CO. (US) | 2006-08-08 | — | — | US | disclosed |