⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6069219 | 1.00 | — | — | |
| SCHEMBL6947208 | 0.69 | — | — | |
| SCHEMBL11168686 | 0.69 | — | — | |
| SCHEMBL6947211 | 0.69 | — | — | |
| SCHEMBL9539435 | 0.69 | — | — | |
| SCHEMBL11168687 | 0.69 | — | — | |
| SCHEMBL15117379 | 0.69 | — | — | |
| SCHEMBL23093029 | 0.67 | — | — | |
| SCHEMBL10801330 | 0.67 | — | — | |
| SCHEMBL10801326 | 0.67 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110128421-B | Simple preparation method of 5-halogenated-7-azaindole | 新发药业有限公司 | 2020-08-11 | — | — | CN | claimed |
| CN-110128421-B | Simple preparation method of 5-halogenated-7-azaindole | 新发药业有限公司 | 2020-08-11 | — | — | CN | disclosed |
| CN-103443093-B | Novel compounds as histamine H3 receptor ligands | SUVEN LIFE SCIENCES LTD | 2015-02-25 | — | — | CN | disclosed |
| US-7060715-B2 | Substituted pyridines as selective cyclooxygenase-2 inhibitors | MERCK FROSST CANADA LTD. (CA) | 2006-06-13 | — | — | US | disclosed |
| US-20050009875-A1 | Substituted pyridines as selective cyclooxygenase-2 inhibitors | MERCK CANADA INC. (CA) | 2005-01-13 | — | — | US | disclosed |
| US-6812346-B2 | ANTIINFLAMMATORY AGENTS; ANTIPYRETICS; ANALGESICS | MERCK FROSST CANADA AND CO. (CA) | 2004-11-02 | — | — | US | disclosed |
| EP-0975596-B1 | PROCESS FOR MAKING 2-ARYL-3-ARYL-5-HALO PYRIDINES USEFUL AS COX-2 INHIBITORS | MERCK & CO INC (US) | 2004-06-30 | — | — | EP | disclosed |
| US-20040029921-A1 | Substituted pyridines as selective cyclooxygenase-2 inhibitors | MERCK FROSST CANADA & CO. | 2004-02-12 | — | — | US | disclosed |
| US-6596736-B2 | Well as a method of treating COX-2 mediated diseases comprising administration to a patient in need of such treatment of a non- toxic therapeutically effective amount of a compound of Formula I. pain, dysmenorrhea, myositis, | MERCK & CO., INC. | 2003-07-22 | — | — | US | disclosed |
| US-20030065011-A1 | Substituted pyridines as selective cyclooxygenase-2 inhibitors | MERCK FROSST CANADA & CO. | 2003-04-03 | — | — | US | disclosed |
| WO-1999015503-A2 | PROCESS FOR MAKING DIARYL PYRIDINES USEFUL AS COX-2 INHIBITORS | MERCK & CO., INC. (US) | 1999-04-01 | — | — | WO | disclosed |
| WO-1998047871-A1 | PROCESS FOR MAKING 2-ARYL-3-ARYL-5-HALO PYRIDINES USEFUL AS COX-2 INHIBITORS | MERCK & CO., INC. (US) | 1998-10-29 | — | — | WO | disclosed |
| EP-0352959-B1 | RESOLUTION PROCESS FOR RACEMIC SPIRO-HYDANTOINS | PFIZER INC. (US) | 1993-09-01 | — | — | EP | disclosed |
| US-5206367-A | Preparation of optically active spiro-hydantoins | PFIZER INC. (US) | 1993-04-27 | — | — | US | disclosed |
| US-5006657-A | Intermediates in a resolution process for racemic spiro hydantoins | PFIZER INC. (US) | 1991-04-09 | — | — | US | disclosed |
| US-4952694-A | Novel resolution process for racemic spiro-hydantoins | PFIZER INC. (US) | 1990-08-28 | — | — | US | disclosed |
| EP-0352959-A1 | Resolution process for racemic spiro-hydantoins | PFIZER INC. (US) | 1990-01-31 | — | — | EP | disclosed |
| EP-0168732-B1 | PROCESS FOR THE PREPARATION OF HALOGENATED AROYLACETIC ACID ESTERS | BAYER AG (DE) | 1988-07-27 | — | — | EP | disclosed |
| EP-0168732-A2 | Process for the preparation of halogenated aroylacetic acid esters | BAYER AG (DE) | 1986-01-22 | — | — | EP | disclosed |
| US-4017484-A | Cationic dyestuffs | BAYER AKTIENGESELLSCHAFT (DT) | 1977-04-12 | — | — | US | disclosed |