Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.56 |
| ▸ | LMNA | P02545 | 3/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.56 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | GFER | P55789 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | GSK3B | P49841 | 8/20 | 0.45 |
| ▸ | CCNB2 | O95067 | 7/20 | 0.45 |
| ▸ | CDK1 | P06493 | 7/20 | 0.45 |
| ▸ | CCNB1 | P14635 | 7/20 | 0.45 |
| ▸ | CDK5 | Q00535 | 7/20 | 0.45 |
| ▸ | CDK5R1 | Q15078 | 7/20 | 0.45 |
| ▸ | CCNB3 | Q8WWL7 | 7/20 | 0.45 |
| ▸ | CDC7 | O00311 | 1/20 | 0.45 |
| ▸ | PLK4 | O00444 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6070573 | 1.00 | MAPT (0.56) | MAPTLMNATDP1HTTNCOA1 | |
| SCHEMBL6454820 | 0.86 | MAPT (0.53) | MAPTLMNATDP1HTTNCOA1 | |
| SCHEMBL13925707 | 0.81 | MAPT (0.53) | MAPTLMNAHTTSMN1; SMN2MEN1 | |
| SCHEMBL6071404 | 0.76 | KDM4E (0.48) | MAPTLMNASMN1; SMN2KMT2ARAB9A | |
| SCHEMBL6071402 | 0.76 | KDM4E (0.48) | MAPTLMNASMN1; SMN2KMT2ARAB9A | |
| SCHEMBL4162219 | 0.73 | MAPT (0.69) | MAPTLMNATDP1HTTNCOA1 | |
| SCHEMBL6239759 | 0.72 | MAPT (1.00) | MAPTLMNATDP1HTTNCOA1 | |
| SCHEMBL14366541 | 0.72 | KDM4E (0.56) | MAPTLMNAHTTSMN1; SMN2MEN1 | |
| SCHEMBL6997551 | 0.72 | MAPT (0.60) | MAPTLMNASMN1; SMN2MEN1KMT2A | |
| SCHEMBL5583246 | 0.72 | KDM4E (0.56) | MAPTLMNAHTTSMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060264493-A1 | Tetracyclic pyrazole derivatives as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | PFIZER ITALIA S.R.L. (IT) | 2006-11-23 | — | — | US | disclosed |
| EP-1599202-A1 | TETRACYCLIC PYRAZOLE DERIVATIVES AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | Pharmacia Italia S.p.A. (IT) | 2005-11-30 | — | — | EP | disclosed |
| WO-2004071507-A1 | TETRACYCLIC PYRAZOLE DERIVATIVES AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | PHARMACIA ITALIA S.P.A. (IT) | 2004-08-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060264493-A1 | Tetracyclic pyrazole derivatives as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | MAP3K1, MAP3K19, MAP3K20 | MAPT 639/4885LMNA 2808/4885TDP1 712/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.