Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK10 | P53779 | 2/20 | 0.62 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.56 |
| ▸ | MEN1 | O00255 | 5/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.56 |
| ▸ | HTR7 | P34969 | 3/20 | 0.56 |
| ▸ | RECQL | P46063 | 3/20 | 0.56 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.56 |
| ▸ | CASP1 | P29466 | 3/20 | 0.56 |
| ▸ | HTR2A | P28223 | 2/20 | 0.56 |
| ▸ | HTR2C | P28335 | 2/20 | 0.56 |
| ▸ | HTR6 | P50406 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 7/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.53 |
| ▸ | HPGD | P15428 | 5/20 | 0.53 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6070322 | 0.90 | MAPK10 (0.62) | MAPK10RIPK1KDM4EKMT2ACYP1A2 | |
| SCHEMBL6071270 | 0.82 | PRKD1 (0.47) | MAPK10RIPK1KDM4EKMT2ACYP1A2 | |
| SCHEMBL6070722 | 0.82 | MAPK10 (0.59) | MAPK10RIPK1KDM4EKMT2AMEN1 | |
| SCHEMBL6070802 | 0.80 | MEN1 (0.49) | MAPK10RIPK1KDM4EKMT2AMEN1 | |
| SCHEMBL6070835 | 0.80 | MPL (0.50) | MAPK10RIPK1KDM4EKMT2AMEN1 | |
| SCHEMBL7132711 | 0.79 | MAPK10 (0.64) | MAPK10RIPK1KDM4EKMT2ACYP1A2 | |
| SCHEMBL6071604 | 0.79 | MAPK10 (0.61) | MAPK10RIPK1KDM4EKMT2AMEN1 | |
| SCHEMBL6070734 | 0.78 | GSK3B (0.47) | MAPK10RIPK1KDM4EKMT2ATDP1 | |
| SCHEMBL1987620 | 0.77 | KDM4E (0.60) | MAPK10RIPK1KDM4EKMT2ACYP1A2 | |
| SCHEMBL6070951 | 0.77 | MAPT (0.55) | KMT2AMEN1TDP1MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060264493-A1 | Tetracyclic pyrazole derivatives as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | PFIZER ITALIA S.R.L. (IT) | 2006-11-23 | — | — | US | claimed |
| US-20060264493-A1 | Tetracyclic pyrazole derivatives as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | PFIZER ITALIA S.R.L. (IT) | 2006-11-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060264493-A1 | Tetracyclic pyrazole derivatives as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | MAP3K1, MAP3K19, MAP3K20 | MAPK10 387/4885RIPK1 131/4885KDM4E 1799/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.