Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK10 | P53779 | 6/20 | 0.61 |
| ▸ | RIPK1 | Q13546 | 6/20 | 0.61 |
| ▸ | FLT3 | P36888 | 6/20 | 0.39 |
| ▸ | ITK | Q08881 | 2/20 | 0.37 |
| ▸ | GSK3B | P49841 | 3/20 | 0.36 |
| ▸ | GSK3A | P49840 | 2/20 | 0.36 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.36 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.36 |
| ▸ | CCNB2 | O95067 | 2/20 | 0.36 |
| ▸ | CDK1 | P06493 | 2/20 | 0.36 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.36 |
| ▸ | CCNB3 | Q8WWL7 | 2/20 | 0.36 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6071604 | 0.90 | MAPK10 (0.61) | MAPK10RIPK1GSK3BGSK3ACDK5 | |
| SCHEMBL6070737 | 0.83 | KDM4E (0.46) | MAPK10RIPK1AURKAAURKBKDM4E | |
| SCHEMBL6071492 | 0.81 | KDM4E (0.51) | MAPK10RIPK1AURKAAURKBKDM4E | |
| SCHEMBL6071274 | 0.81 | MAPK10 (0.41) | MAPK10RIPK1GSK3BGSK3ACDK5 | |
| SCHEMBL6071412 | 0.81 | MAPK10 (0.46) | MAPK10RIPK1AURKAAURKBKDM4E | |
| SCHEMBL6071032 | 0.81 | MAPK10 (0.59) | MAPK10RIPK1AURKAAURKBKDM4E | |
| SCHEMBL6070322 | 0.79 | MAPK10 (0.62) | MAPK10RIPK1KDM4EMEN1ALDH1A1 | |
| SCHEMBL6070531 | 0.79 | MAPK10 (0.60) | MAPK10RIPK1 | |
| SCHEMBL6070880 | 0.77 | MPL (0.57) | MAPK10RIPK1ITKGSK3BGSK3A | |
| SCHEMBL6071081 | 0.76 | MAPT (0.44) | MAPK10RIPK1GSK3BCDK5CDK5R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060264493-A1 | Tetracyclic pyrazole derivatives as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | PFIZER ITALIA S.R.L. (IT) | 2006-11-23 | — | — | US | claimed |
| US-20060264493-A1 | Tetracyclic pyrazole derivatives as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | PFIZER ITALIA S.R.L. (IT) | 2006-11-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060264493-A1 | Tetracyclic pyrazole derivatives as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | MAP3K1, MAP3K19, MAP3K20 | MAPK10 387/4885RIPK1 131/4885FLT3 451/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.