Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.51 |
| ▸ | HPGD | P15428 | 3/20 | 0.51 |
| ▸ | MAPK10 | P53779 | 12/20 | 0.50 |
| ▸ | RIPK1 | Q13546 | 10/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | TLR9 | Q9NR96 | 2/20 | 0.47 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.47 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.47 |
| ▸ | AURKA | O14965 | 1/20 | 0.47 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | MPI | P34949 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6071258 | 0.93 | KDM4E (0.58) | KDM4EALDH1A1HSD17B10HPGDMAPK10 | |
| SCHEMBL6071283 | 0.90 | MAPK10 (0.53) | KDM4EALDH1A1HSD17B10HPGDMAPK10 | |
| SCHEMBL6070769 | 0.90 | MAPK10 (0.53) | KDM4EALDH1A1HSD17B10HPGDMAPK10 | |
| SCHEMBL6071265 | 0.88 | MAPK10 (0.55) | KDM4EALDH1A1HSD17B10HPGDMAPK10 | |
| SCHEMBL14366580 | 0.87 | KDM4E (0.56) | KDM4EALDH1A1HSD17B10HPGDMAPK10 | |
| Hydrochloric Acid SCHEMBL5583223 | 0.86 | KDM4E (0.56) | KDM4EALDH1A1HSD17B10HPGDMAPK10 | |
| SCHEMBL6071646 | 0.85 | MAPK10 (0.57) | KDM4EALDH1A1HSD17B10HPGDMAPK10 | |
| SCHEMBL14366581 | 0.85 | KDM4E (0.53) | KDM4EALDH1A1HSD17B10HPGDMAPK10 | |
| Hydrochloric Acid SCHEMBL5583161 | 0.84 | KDM4E (0.52) | KDM4EALDH1A1HSD17B10HPGDMAPK10 | |
| SCHEMBL6071184 | 0.83 | MAPK10 (0.54) | KDM4EALDH1A1HSD17B10HPGDMAPK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060264493-A1 | Tetracyclic pyrazole derivatives as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | PFIZER ITALIA S.R.L. (IT) | 2006-11-23 | — | — | US | claimed |
| US-20060264493-A1 | Tetracyclic pyrazole derivatives as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | PFIZER ITALIA S.R.L. (IT) | 2006-11-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060264493-A1 | Tetracyclic pyrazole derivatives as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | MAP3K1, MAP3K19, MAP3K20 | KDM4E 1799/4885ALDH1A1 4446/4885HSD17B10 4387/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.