Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK10 | P53779 | 2/20 | 0.50 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.50 |
| ▸ | AURKA | O14965 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | CLEC4M | Q9H2X3 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | CDK1 | P06493 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | CDC25B | P30305 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | JAK2 | O60674 | 2/20 | 0.35 |
| ▸ | JAK3 | P52333 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.35 |
| ▸ | CCR6 | P51684 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | GABRP | O00591 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6070436 | 0.88 | NR4A2 (0.41) | MAPK10RIPK1AURKAKDM4EJAK2 | |
| SCHEMBL6070636 | 0.84 | PARP1 (0.42) | MAPK10RIPK1AURKAPARP1 | |
| SCHEMBL6070790 | 0.79 | MAPK10 (0.43) | MAPK10RIPK1AURKAKDM4ETSHR | |
| SCHEMBL6070444 | 0.77 | MAPK10 (0.41) | MAPK10RIPK1AURKAKDM4ETSHR | |
| SCHEMBL6071266 | 0.77 | KDM4E (0.62) | MAPK10RIPK1AURKAKDM4ECDK1 | |
| SCHEMBL6071199 | 0.77 | AURKA (0.53) | MAPK10RIPK1AURKAKDM4ECDK1 | |
| SCHEMBL6071122 | 0.74 | MAPK10 (0.41) | MAPK10RIPK1AURKAKDM4ETSHR | |
| SCHEMBL6071516 | 0.74 | MAPK10 (0.59) | MAPK10RIPK1AURKAKDM4ETSHR | |
| SCHEMBL6070557 | 0.74 | MAPK10 (0.41) | MAPK10RIPK1AURKAKDM4ETSHR | |
| SCHEMBL6009595 | 0.73 | TSHR (0.61) | KDM4ECLEC4MTSHRCDK1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060264493-A1 | Tetracyclic pyrazole derivatives as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | PFIZER ITALIA S.R.L. (IT) | 2006-11-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060264493-A1 | Tetracyclic pyrazole derivatives as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | MAP3K1, MAP3K19, MAP3K20 | MAPK10 387/4885RIPK1 131/4885AURKA 249/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.