Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 5/20 | 0.58 |
| ▸ | MAP3K8 | P41279 | 17/20 | 0.57 |
| ▸ | MAPKAPK2 | P49137 | 2/20 | 0.56 |
| ▸ | LCK | P06239 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.56 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.56 |
| ▸ | SRC | P12931 | 1/20 | 0.54 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.54 |
| ▸ | CAMK2B | Q13554 | 1/20 | 0.54 |
| ▸ | CAMK2G | Q13555 | 1/20 | 0.54 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.54 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4960392 | 0.87 | MAP3K8 (0.69) | EGFRMAP3K8MAPKAPK2LCKCYP3A4 | |
| SCHEMBL6071729 | 0.86 | MAP3K8 (0.61) | EGFRMAP3K8MAPKAPK2CYP3A4 | |
| SCHEMBL2278586 | 0.86 | MAP3K8 (0.69) | EGFRMAP3K8MAPKAPK2LCKCYP3A4 | |
| SCHEMBL6071904 | 0.85 | MAP3K8 (0.60) | EGFRMAP3K8MAPKAPK2LCKCYP3A4 | |
| SCHEMBL6071670 | 0.83 | MAP3K8 (0.66) | EGFRMAP3K8MAPKAPK2LCKCYP3A4 | |
| SCHEMBL6071150 | 0.83 | MAP3K8 (0.55) | EGFRMAP3K8MAPKAPK2LCKCYP3A4 | |
| SCHEMBL6071367 | 0.83 | MAP3K8 (0.68) | EGFRMAP3K8MAPKAPK2LCKCYP3A4 | |
| SCHEMBL6071446 | 0.82 | MAP3K8 (0.57) | EGFRMAP3K8MAPKAPK2LCKCYP3A4 | |
| SCHEMBL6072012 | 0.81 | MAP3K8 (0.58) | EGFRMAP3K8MAPKAPK2LCKCYP3A4 | |
| SCHEMBL4960484 | 0.81 | MAP3K8 (0.67) | EGFRMAP3K8MAPKAPK2CYP3A4SRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060264460-A1 | 3-Cyanoquinoline inhibitors of Tpl2 kinase and methods of making and using the same | WYETH (US) | 2006-11-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060264460-A1 | 3-Cyanoquinoline inhibitors of Tpl2 kinase and methods of making and using the same | TNNI3K, CSNK1A1L, CDKL1 | EGFR 4122/4885MAP3K8 84/4885MAPKAPK2 110/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.