Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K8 | P41279 | 9/20 | 0.61 |
| ▸ | EGFR | P00533 | 12/20 | 0.51 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.46 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.46 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.46 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.46 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6071502 | 0.90 | MAP3K8 (0.64) | MAP3K8EGFRMAPK13EIF2AK2MAPK12 | |
| SCHEMBL6071264 | 0.86 | MAP3K8 (0.72) | MAP3K8EGFRMAPK14 | |
| SCHEMBL4960392 | 0.84 | MAP3K8 (0.69) | MAP3K8EGFRMAPK14 | |
| SCHEMBL6071655 | 0.83 | MAP3K8 (0.75) | MAP3K8EGFRMAPK13EIF2AK2MAPK12 | |
| SCHEMBL4960401 | 0.83 | MAP3K8 (0.67) | MAP3K8EGFRMAPK13EIF2AK2MAPK12 | |
| SCHEMBL6071770 | 0.80 | MAP3K8 (0.50) | MAP3K8EGFRERBB2 | |
| SCHEMBL4960699 | 0.79 | MAP3K8 (0.61) | MAP3K8EGFRMAPK13EIF2AK2MAPK12 | |
| SCHEMBL6071741 | 0.78 | CNR2 (0.46) | MAP3K8EGFRMAPK13EIF2AK2MAPK12 | |
| SCHEMBL6071729 | 0.78 | MAP3K8 (0.61) | MAP3K8EGFRERBB2 | |
| SCHEMBL6071363 | 0.76 | MAP3K8 (0.71) | MAP3K8EGFRMAPK13MAPK12MAPK11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060264460-A1 | 3-Cyanoquinoline inhibitors of Tpl2 kinase and methods of making and using the same | WYETH (US) | 2006-11-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060264460-A1 | 3-Cyanoquinoline inhibitors of Tpl2 kinase and methods of making and using the same | TNNI3K, CSNK1A1L, CDKL1 | MAP3K8 84/4885EGFR 4122/4885MAPK13 863/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.