Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 19/20 | 0.71 |
| ▸ | ERBB2 | P04626 | 6/20 | 0.71 |
| ▸ | STK25 | O00506 | 1/20 | 0.58 |
| ▸ | CIT | O14578 | 1/20 | 0.58 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.58 |
| ▸ | GAK | O14976 | 1/20 | 0.58 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.58 |
| ▸ | JAK2 | O60674 | 1/20 | 0.58 |
| ▸ | STK17B | O94768 | 1/20 | 0.58 |
| ▸ | STK10 | O94804 | 1/20 | 0.58 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.58 |
| ▸ | ABL1 | P00519 | 1/20 | 0.58 |
| ▸ | LCK | P06239 | 1/20 | 0.58 |
| ▸ | FYN | P06241 | 1/20 | 0.58 |
| ▸ | FES | P07332 | 1/20 | 0.58 |
| ▸ | CSF1R | P07333 | 1/20 | 0.58 |
| ▸ | YES1 | P07947 | 1/20 | 0.58 |
| ▸ | LYN | P07948 | 1/20 | 0.58 |
| ▸ | MET | P08581 | 1/20 | 0.58 |
| ▸ | HCK | P08631 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6072001 | 0.92 | EGFR (0.59) | EGFRERBB2STK25CITCHEK1 | |
| SCHEMBL4968151 | 0.91 | EGFR (0.59) | EGFRERBB2STK25CITCHEK1 | |
| SCHEMBL4967268 | 0.91 | EGFR (0.59) | EGFRERBB2STK25CITCHEK1 | |
| SCHEMBL6070981 | 0.86 | MAP3K8 (0.73) | EGFRERBB2ABL1FYNBCR | |
| SCHEMBL4964899 | 0.84 | MAP3K8 (0.54) | EGFRERBB2SRCMAP3K8MAPK13 | |
| SCHEMBL6383515 | 0.84 | EGFR (1.00) | EGFRERBB2STK25CITCHEK1 | |
| SCHEMBL4965565 | 0.83 | MAP3K8 (0.53) | EGFRERBB2SRCMAP2K1PRKCD | |
| SCHEMBL6071778 | 0.82 | MAP3K8 (0.74) | EGFRERBB2STK25CITCHEK1 | |
| SCHEMBL6071783 | 0.82 | MAP3K8 (0.57) | EGFRERBB2SRCMAP2K1PRKCD | |
| SCHEMBL6072168 | 0.81 | MAP3K8 (0.52) | EGFRERBB2SRCMAP2K1PRKCD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101223143-A | 3-cyanoquinoline inhibitors of TPL2 kinase and methods of making and using the same | WYETH CORP (US) | 2008-07-16 | — | — | CN | disclosed |
| US-20060264460-A1 | 3-Cyanoquinoline inhibitors of Tpl2 kinase and methods of making and using the same | WYETH (US) | 2006-11-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060264460-A1 | 3-Cyanoquinoline inhibitors of Tpl2 kinase and methods of making and using the same | TNNI3K, CSNK1A1L, CDKL1 | EGFR 4122/4885ERBB2 1721/4885STK25 122/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.