Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCND3 | P30281 | 3/20 | 0.51 |
| ▸ | CDK2 | P24941 | 2/20 | 0.51 |
| ▸ | CCNK | O75909 | 1/20 | 0.51 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.51 |
| ▸ | CDK9 | P50750 | 1/20 | 0.51 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.51 |
| ▸ | SYK | P43405 | 3/20 | 0.49 |
| ▸ | CDK4 | P11802 | 3/20 | 0.48 |
| ▸ | CCND1 | P24385 | 3/20 | 0.48 |
| ▸ | CCND2 | P30279 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | JAK3 | P52333 | 5/20 | 0.46 |
| ▸ | JAK2 | O60674 | 3/20 | 0.46 |
| ▸ | EGFR | P00533 | 1/20 | 0.44 |
| ▸ | NAMPT | P43490 | 1/20 | 0.43 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6074107 | 0.94 | CDK2 (0.51) | CCND3CDK2CCNKCCNA2CDK9 | |
| SCHEMBL7066974 | 0.88 | ALK (0.45) | CCND3CDK2SYKCDK4CCND1 | |
| SCHEMBL6073647 | 0.88 | CDK2 (0.56) | CCND3CDK2CCNKCCNA2CDK9 | |
| SCHEMBL6073789 | 0.86 | CCND3 (0.53) | CCND3CDK2CCNKCCNA2CDK9 | |
| SCHEMBL6074138 | 0.86 | CDK2 (0.58) | CCND3CDK2CCNKCCNA2CDK9 | |
| SCHEMBL6073911 | 0.85 | CDK2 (0.54) | CCND3CDK2CCNKCCNA2CDK9 | |
| SCHEMBL6073717 | 0.85 | CDK4 (0.54) | CCND3CDK2CCNKCCNA2CDK9 | |
| SCHEMBL6074561 | 0.84 | CDK4 (0.49) | CCND3CDK2CCNA2SYKCDK4 | |
| SCHEMBL6073565 | 0.84 | CCND3 (0.53) | CCND3CDK2CCNKCCNA2CDK9 | |
| SCHEMBL6074236 | 0.84 | CDK2 (0.53) | CCND3CDK2CCNKCCNA2CDK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7053070-B2 | Pyrido[2,3-d]pyrimidine-2,7-diamine kinase inhibitors | WARNER-LAMBERT COMPANY (US) | 2006-05-30 | — | — | US | disclosed |