⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL548023 | 0.97 | — | — | |
| SCHEMBL127287 | 0.94 | — | — | |
| SCHEMBL129414 | 0.88 | — | — | |
| SCHEMBL131173 | 0.77 | — | — | |
| SCHEMBL129702 | 0.75 | — | — | |
| SCHEMBL7144770 | 0.72 | — | — | |
| SCHEMBL27563382 | 0.70 | SLC6A2 (0.32) | — | |
| SCHEMBL127688 | 0.69 | — | — | |
| SCHEMBL497974 | 0.69 | — | — | |
| SCHEMBL2293900 | 0.67 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7022690-B2 | Carboxylic acid substituted heterocycles, derivatives thereof and methods of use | AMGEN INC. (US) | 2006-04-04 | — | — | US | disclosed |
| US-20050159407-A1 | Carboxylic acid substituted heterocycles, derivatives thereof and methods of use | AMGEN INC. | 2005-07-21 | — | — | US | disclosed |
| US-6838454-B2 | Carboxylic acid substituted heterocycles, derivatives thereof and methods of use | AMGEN INC. (US) | 2005-01-04 | — | — | US | disclosed |
| WO-2004032871-A2 | PIPERAZINE AND PIPERAZINONE INHIBITORS OF FACTOR XA | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2004-04-22 | — | — | WO | disclosed |
| EP-0948495-B1 | ARYL AND HETEROARYL SUBSTITUTED FUSED PYRROLE ANTIINFLAMMATORY AGENTS | AMGEN INC (US) | 2004-04-14 | — | — | EP | disclosed |
| US-20040029863-A1 | Carboxylic acid substituted heterocycles, derivatives thereof and methods of use | AMGEN INC. | 2004-02-12 | — | — | US | disclosed |
| US-6605634-B2 | Tumor necrosis factor alpha and interleukin-1 (IL-1) mediated diseases; pain, diabetes; cyclooxygenase inhibition | AMGEN, INC. | 2003-08-12 | — | — | US | disclosed |
| US-6593351-B2 | 3-Sulfonylamino-c5 to c8-methyleneimino-2-carboxylic acid compound is effective for prophylaxis and treatment of inflammation, tissue degradation, cancer, fibrosis and related diseases | AMGEN INC. | 2003-07-15 | — | — | US | disclosed |
| US-20030096819-A1 | Aryl and heteroaryl substituted fused pyrrole anti-inflammatory agents | AMGEN INC. | 2003-05-22 | — | — | US | disclosed |
| EP-1042297-B1 | CARBOXYL ACID SUBSTITUTED HETEROCYCLES AS METALLOPROTEINASE INHIBITORS | AMGEN INC (US) | 2003-02-26 | — | — | EP | disclosed |
| EP-1042297-A1 | CARBOXYL ACID SUBSTITUTED HETEROCYCLES AS METALLOPROTEINASE INHIBITORS | Amgen Inc. (US) | 2000-10-11 | — | — | EP | disclosed |
| EP-1040099-A1 | AZEPINE OR LARGER MEDIUM RING DERIVATIVES AND THEIR USE AS PHARMACEUTICALS | Amgen Inc., (US) | 2000-10-04 | — | — | EP | disclosed |
| US-6107291-A | ANTIINFLAMMATORY AGENT | AMGEN INC. (US) | 2000-08-22 | — | — | US | disclosed |
| EP-1003751-A1 | HYDROXAMIC ACID SUBSTITUTED FUSED HETEROCYCLIC METALLOPROTEINASE INHIBITORS | AMGEN INC. (US) | 2000-05-31 | — | — | EP | disclosed |
| EP-0948495-A1 | ARYL AND HETEROARYL SUBSTITUTED FUSED PYRROLE ANTIINFLAMMATORY AGENTS | Amgen Inc., (US) | 1999-10-13 | — | — | EP | disclosed |
| WO-1999032451-A1 | AZEPINE OR LARGER MEDIUM RING DERIVATIVES AND THEIR USE AS PHARMACEUTICALS | AMGEN INC. (US) | 1999-07-01 | — | — | WO | disclosed |
| WO-1999032452-A1 | CARBOXYL ACID SUBSTITUTED HETEROCYCLES AS METALLOPROTEINASE INHIBITORS | AMGEN INC. (US) | 1999-07-01 | — | — | WO | disclosed |
| WO-1999006410-A1 | HYDROXAMIC ACID SUBSTITUTED FUSED HETEROCYCLIC METALLOPROTEINASE INHIBITORS | AMGEN INC. (US) | 1999-02-11 | — | — | WO | disclosed |
| WO-1998022457-A9 | ARYL AND HETEROARYL SUBSTITUTED FUSED PYRROLE ANTIINFLAMMATORY AGENTS | — | 1998-08-20 | — | — | WO | disclosed |
| WO-1998022457-A1 | ARYL AND HETEROARYL SUBSTITUTED FUSED PYRROLE ANTIINFLAMMATORY AGENTS | AMGEN INC. (US) | 1998-05-28 | — | — | WO | disclosed |