Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 6/20 | 0.77 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.77 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.77 |
| ▸ | TSPO | P30536 | 1/20 | 0.77 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.77 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.77 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.77 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | DPP4 | P27487 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL609325 | 0.89 | GRM5 (0.66) | GRM5KCNH2ADRB3TSPOTMEM97 | |
| SCHEMBL607411 | 0.88 | GRM5 (0.82) | GRM5KCNH2ADRB3TSPOTMEM97 | |
| SCHEMBL607722 | 0.88 | GRM5 (0.82) | GRM5KCNH2ADRB3TSPOTMEM97 | |
| SCHEMBL608557 | 0.87 | GRM5 (0.73) | GRM5KCNH2ADRB3TSPOTMEM97 | |
| SCHEMBL608379 | 0.87 | GRM5 (1.00) | GRM5KCNH2ADRB3TSPOTMEM97 | |
| SCHEMBL29355575 | 0.87 | GRM5 (1.00) | GRM5KCNH2ADRB3TSPOTMEM97 | |
| Basimglurant SCHEMBL560590 | 0.86 | GRM5 (1.00) | GRM5KCNH2ADRB3TSPOTMEM97 | |
| Basimglurant SCHEMBL29377966 | 0.86 | GRM5 (1.00) | GRM5KCNH2ADRB3TSPOTMEM97 | |
| SCHEMBL607714 | 0.85 | GRM5 (0.73) | GRM5KCNH2ADRB3TSPOTMEM97 | |
| SCHEMBL608763 | 0.84 | GRM5 (0.68) | GRM5KCNH2ADRB3TSPOTMEM97 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 40 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220241260-A9 | Pharmaceutical Compositions Of Metabotropic Glutamate 5 Receptor (MGLU5) Antagonists | HOFFMANN LA ROCHE (CH) | 2022-08-04 | — | — | US | claimed |
| US-20210052567-A1 | Pharmaceutical Compositions Of Metabotropic Glutamate 5 Receptor (MGLU5) Antagonists | HOFFMANN LA ROCHE (CH) | 2021-02-25 | — | — | US | claimed |
| US-20190216789-A1 | Pharmaceutical Compositions Of Metabotropic Glutamate 5 Receptor (MGLU5) Antagonists | HOFFMANN LA ROCHE (CH) | 2019-07-18 | — | — | US | claimed |
| US-20170202819-A1 | PHARMACEUTICAL COMPOSITIONS OF METABOTROPIC GLUTAMATE 5 RECEPTOR (MGLU5) ANTAGONISTS | F. HOFFMANN-LA ROCHE AG | 2017-07-20 | — | — | US | claimed |
| US-20150140087-A1 | Pharmaceutical Compositions Of Metabotropic Glutamate 5 Receptor (MGLU5) Antagonists | HOFFMANN-LA ROCHE INC. | 2015-05-21 | — | — | US | claimed |
| EP-2808022-A1 | Pharmaceutical compositions of metabotropic glutamate 5 receptor (MGLU5) antagonists | F. Hoffmann-La Roche AG (CH) | 2014-12-03 | — | — | EP | claimed |
| EP-2603203-A2 | PHARMACEUTICAL COMPOSITIONS OF METABOTROPIC GLUTAMATE 5 RECEPTOR (MGLU5) ANTAGONISTS | F.HOFFMANN-LA ROCHE AG (CH) | 2013-06-19 | — | — | EP | claimed |
| EP-2603206-A2 | PHARMACEUTICAL COMPOSITIONS OF METABOTROPIC GLUTAMATE 5 RECEPTOR (MGLU5) ANTAGONISTS | F.HOFFMANN-LA ROCHE AG (CH) | 2013-06-19 | — | — | EP | claimed |
| US-8293916-B2 | Diazole derivatives | HOFFMANN-LA ROCHE INC. (US) | 2012-10-23 | — | — | US | claimed |
| WO-2012019989-A2 | PHARMACEUTICAL COMPOSITIONS OF METABOTROPIC GLUTAMATE 5 RECEPTOR (MGLU5) ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2012-02-16 | — | — | WO | claimed |
| WO-2012019990-A2 | PHARMACEUTICAL COMPOSITIONS OF METABOTROPIC GLUTAMATE 5 RECEPTOR (MGLU5) ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2012-02-16 | — | — | WO | claimed |
| US-20120039999-A1 | PHARMACEUTICAL COMPOSITIONS OF METABOTROPIC GLUTAMATE 5 RECEPTOR (MGLU5) ANTAGONISTS | CHATTERJI ASHISH (US) | 2012-02-16 | — | — | US | claimed |
| JP-4690395-B2 | — | — | 2011-06-01 | — | — | JP | claimed |
| US-20100048569-A1 | DIAZOLE DERIVATIVES | BUETTELMANN BERND | 2010-02-25 | — | — | US | claimed |
| US-20090054490-A1 | METHODS FOR THE TREATMENT OF GERD WITH MGLUR5 ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-02-26 | — | — | US | claimed |
| WO-2009024491-A1 | USE OF MGLUR5 ANTAGONISTS FOR THE TREATMENT OF GERD | F. HOFFMANN-LA ROCHE AG (CH) | 2009-02-26 | — | — | WO | claimed |
| EP-1756086-B1 | PYRIDIN-4-YL-ETHYNYL-IMIDAZOLES AND PYRAZOLES AS MGLU5 RECEPTOR ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2008-06-04 | — | — | EP | claimed |
| EP-1756086-A1 | PYRIDIN-4-YL-ETHYNYL-IMIDAZOLES AND PYRAZOLES AS MGLU5 RECEPTOR ANTAGONISTS | F.HOFFMANN-LA ROCHE AG (CH) | 2007-02-28 | — | — | EP | claimed |
| US-20060030559-A1 | Diazole derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 2006-02-09 | — | — | US | claimed |
| WO-2005118568-A1 | PYRIDIN-4-YL-ETHYNYL-IMIDAZOLES AND PYRAZOLES AS MGLU5 RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-12-15 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100048569-A1 | DIAZOLE DERIVATIVES | GRM1, GRM2, GRIN2B | GRM5 14/4885KCNH2 551/4885ADRB3 1151/4885 |
| US-20060030559-A1 | Diazole derivatives | GRM1, GRM2, GRIN2B | GRM5 14/4885KCNH2 551/4885ADRB3 1151/4885 |
| US-20190216789-A1 | Pharmaceutical Compositions Of Metabotropic Glutamate 5 Receptor (MGLU5) Antagonists | GRM5, GRIK5, GRM1 | GRM5 1/4885KCNH2 1493/4885ADRB3 3062/4885 |
| US-20170202819-A1 | PHARMACEUTICAL COMPOSITIONS OF METABOTROPIC GLUTAMATE 5 RECEPTOR (MGLU5) ANTAGONISTS | GRM5, GRIK5, GRM1 | GRM5 1/4885KCNH2 1623/4885ADRB3 2755/4885 |
| US-20090054490-A1 | METHODS FOR THE TREATMENT OF GERD WITH MGLUR5 ANTAGONISTS | GRM5, HRH2, GRPR | GRM5 1/4885KCNH2 1043/4885ADRB3 533/4885 |
| US-20120039999-A1 | PHARMACEUTICAL COMPOSITIONS OF METABOTROPIC GLUTAMATE 5 RECEPTOR (MGLU5) ANTAGONISTS | GRM5, GRIK5, GRM1 | GRM5 1/4885KCNH2 1623/4885ADRB3 2755/4885 |
| US-20220241260-A9 | Pharmaceutical Compositions Of Metabotropic Glutamate 5 Receptor (MGLU5) Antagonists | GRM5, GRIK5, GRM1 | GRM5 1/4885KCNH2 1623/4885ADRB3 2755/4885 |
| US-20150140087-A1 | Pharmaceutical Compositions Of Metabotropic Glutamate 5 Receptor (MGLU5) Antagonists | GRM5, GRIK5, GRM1 | GRM5 1/4885KCNH2 1623/4885ADRB3 2755/4885 |
| US-20210052567-A1 | Pharmaceutical Compositions Of Metabotropic Glutamate 5 Receptor (MGLU5) Antagonists | GRM5, GRIK5, GRM1 | GRM5 1/4885KCNH2 1623/4885ADRB3 2755/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.