Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 14/20 | 0.78 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.78 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.78 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.78 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.78 |
| ▸ | KIT | P10721 | 9/20 | 0.73 |
| ▸ | PDGFRA | P16234 | 9/20 | 0.73 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.72 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.72 |
| ▸ | PLK4 | O00444 | 1/20 | 0.72 |
| ▸ | AURKA | O14965 | 1/20 | 0.72 |
| ▸ | GAK | O14976 | 1/20 | 0.72 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.72 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.72 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.72 |
| ▸ | CA12 | O43570 | 1/20 | 0.72 |
| ▸ | PIP5K1C | O60331 | 1/20 | 0.72 |
| ▸ | JAK2 | O60674 | 1/20 | 0.72 |
| ▸ | STK16 | O75716 | 1/20 | 0.72 |
| ▸ | STK10 | O94804 | 1/20 | 0.72 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6083872 | 0.93 | KDR (0.74) | KDRCYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL31672447 | 0.92 | KDR (0.75) | KDRCYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL10151189 | 0.92 | KDR (0.75) | KDRCYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL5799466 | 0.92 | KDR (0.74) | KDRCYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL6079749 | 0.89 | KDR (0.71) | KDRCYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL589379 | 0.88 | KDR (0.98) | KDRCYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL15973690 | 0.88 | KDR (0.79) | KDRCYP3A4CYP2D6CYP2C9CYP2C19 | |
| Hydrochloric Acid SCHEMBL27218213 | 0.87 | KDR (1.00) | KDRCYP3A4CYP2D6CYP2C9CYP2C19 | |
| Hydrochloric Acid SCHEMBL27218215 | 0.87 | KDR (1.00) | KDRCYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL14419341 | 0.85 | KDR (0.84) | KDRCYP3A4CYP2D6CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060252943-A1 | Chemical process | SMITHKLINE BEECHAM CORPORATION | 2006-11-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060252943-A1 | Chemical process | KDR, FLT4, FLT1 | KDR 1/4885CYP3A4 595/4885CYP2D6 757/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.