Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 6/20 | 0.56 |
| ▸ | CDK2 | P24941 | 8/20 | 0.52 |
| ▸ | CDK4 | P11802 | 5/20 | 0.52 |
| ▸ | CCND1 | P24385 | 3/20 | 0.52 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.52 |
| ▸ | CDK1 | P06493 | 1/20 | 0.52 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.52 |
| ▸ | JAK2 | O60674 | 2/20 | 0.48 |
| ▸ | JAK3 | P52333 | 2/20 | 0.48 |
| ▸ | CCNA2 | P20248 | 4/20 | 0.48 |
| ▸ | AURKA | O14965 | 3/20 | 0.48 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.48 |
| ▸ | CCND3 | P30281 | 2/20 | 0.48 |
| ▸ | CDK6 | Q00534 | 2/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | PIM1 | P11309 | 1/20 | 0.47 |
| ▸ | TTK | P33981 | 1/20 | 0.47 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.47 |
| ▸ | JAK1 | P23458 | 1/20 | 0.46 |
| ▸ | IGF1R | P08069 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6088548 | 0.92 | CDK2 (0.59) | SYKCDK2CDK4CCND1CCNE1 | |
| SCHEMBL6087387 | 0.91 | CDK4 (0.59) | SYKCDK2CDK4CCND1CCNE1 | |
| SCHEMBL6087577 | 0.91 | SYK (0.56) | SYKCDK2CDK4CCND1CCNE1 | |
| SCHEMBL6089542 | 0.87 | CDK4 (0.51) | SYKCDK2CDK4CCND1CCNE1 | |
| SCHEMBL6086413 | 0.87 | SYK (0.53) | SYKCDK2CDK4CCND1CCNE1 | |
| SCHEMBL6087448 | 0.86 | SYK (0.47) | SYKCDK2CDK4CCND1CCNE1 | |
| SCHEMBL6088740 | 0.86 | CDK2 (0.46) | SYKCDK2CDK4CCND1CCNE1 | |
| SCHEMBL7475319 | 0.84 | CDK2 (0.46) | SYKCDK2CDK4CCND1CCNE1 | |
| SCHEMBL6086831 | 0.83 | CDK4 (0.61) | SYKCDK2CDK4CCND1CCNE1 | |
| SCHEMBL6088759 | 0.83 | CDK2 (0.66) | SYKCDK2CDK4CCND1CCNE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1235815-A1 | QUINAZOLINES AND THEIR USE FOR INHIBITING CYCLIN-DEPENDENT KINASE ENZYMES | WARNER-LAMBERT COMPANY (US) | 2002-09-04 | — | — | EP | claimed |
| WO-2001038315-A1 | QUINAZOLINES AND THEIR USE FOR INHIBITING CYCLIN-DEPENDENT KINASE ENZYMES | WARNER-LAMBERT COMPANY (US) | 2001-05-31 | — | — | WO | claimed |
| US-6982260-B1 | Quinazolines and their use for inhibiting cyclin-dependent kinase enzymes | WARNER-LAMBERT COMPANY (US) | 2006-01-03 | — | — | US | disclosed |