Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 20/20 | 0.62 |
| ▸ | CCND1 | P24385 | 16/20 | 0.62 |
| ▸ | CCND2 | P30279 | 6/20 | 0.61 |
| ▸ | CCND3 | P30281 | 6/20 | 0.61 |
| ▸ | CDK2 | P24941 | 5/20 | 0.54 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.54 |
| ▸ | CDK1 | P06493 | 4/20 | 0.47 |
| ▸ | CCNB1 | P14635 | 4/20 | 0.47 |
| ▸ | CCNE1 | P24864 | 4/20 | 0.47 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.46 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.46 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.46 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.46 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.46 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6087163 | 0.89 | CDK4 (0.63) | CDK4CCND1CCND2CCND3CDK2 | |
| SCHEMBL6087762 | 0.89 | CDK4 (0.79) | CDK4CCND1CCND2CCND3CDK2 | |
| SCHEMBL6088982 | 0.88 | CDK4 (0.78) | CDK4CCND1CCND2CCND3CDK2 | |
| SCHEMBL6086615 | 0.88 | CDK4 (0.62) | CDK4CCND1CCND2CCND3CDK2 | |
| SCHEMBL7465457 | 0.88 | CDK4 (0.74) | CDK4CCND1CCND2CCND3CDK2 | |
| SCHEMBL6090404 | 0.88 | CDK4 (0.57) | CDK4CCND1CCND2CCND3CDK2 | |
| SCHEMBL6087775 | 0.87 | CDK4 (0.79) | CDK4CCND1CCND2CCND3CDK2 | |
| SCHEMBL6087241 | 0.84 | CDK4 (0.63) | CDK4CCND1CCND2CCND3CDK2 | |
| SCHEMBL6088101 | 0.81 | CDK4 (0.77) | CDK4CCND1CCND2CCND3CDK2 | |
| SCHEMBL6087685 | 0.80 | CDK4 (0.60) | CDK4CCND1CCND2CCND3CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6982260-B1 | Quinazolines and their use for inhibiting cyclin-dependent kinase enzymes | WARNER-LAMBERT COMPANY (US) | 2006-01-03 | — | — | US | disclosed |