Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 13/20 | 0.58 |
| ▸ | CCND1 | P24385 | 11/20 | 0.58 |
| ▸ | CDK2 | P24941 | 8/20 | 0.58 |
| ▸ | CDK1 | P06493 | 6/20 | 0.58 |
| ▸ | CCNB1 | P14635 | 6/20 | 0.58 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.58 |
| ▸ | CCNA2 | P20248 | 5/20 | 0.54 |
| ▸ | CCND3 | P30281 | 3/20 | 0.54 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.54 |
| ▸ | CCNT1 | O60563 | 3/20 | 0.51 |
| ▸ | CDK7 | P50613 | 3/20 | 0.51 |
| ▸ | CDK9 | P50750 | 3/20 | 0.51 |
| ▸ | CCNH | P51946 | 3/20 | 0.51 |
| ▸ | BRD4 | O60885 | 2/20 | 0.49 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.48 |
| ▸ | CCND2 | P30279 | 1/20 | 0.47 |
| ▸ | IGF1R | P08069 | 1/20 | 0.47 |
| ▸ | FLT3 | P36888 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6086207 | 0.91 | CDK4 (0.56) | CDK4CCND1CDK2CDK1CCNB1 | |
| SCHEMBL6086788 | 0.87 | CDK4 (0.57) | CDK4CCND1CDK2CDK1CCNB1 | |
| SCHEMBL6089233 | 0.85 | CDK2 (0.60) | CDK4CCND1CDK2CCNE1CCNA2 | |
| SCHEMBL7459536 | 0.83 | CDK2 (0.46) | CDK4CCND1CDK2CDK1CCNB1 | |
| SCHEMBL6088159 | 0.83 | CDK2 (0.60) | CDK4CCND1CDK2CDK1CCNB1 | |
| SCHEMBL7470120 | 0.83 | CDK2 (0.47) | CDK4CCND1CDK2CDK1CCNB1 | |
| SCHEMBL6087131 | 0.83 | SYK (0.53) | CDK4CCND1CDK2CDK1CCNB1 | |
| SCHEMBL6086902 | 0.83 | CDK4 (0.61) | CDK4CCND1CDK2CDK1CCNB1 | |
| SCHEMBL6086487 | 0.83 | IGF1R (0.46) | CDK4CCND1CDK2CDK1CCNB1 | |
| SCHEMBL6086415 | 0.82 | CDK2 (0.51) | CDK4CCND1CDK2CDK1CCNB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1235815-A1 | QUINAZOLINES AND THEIR USE FOR INHIBITING CYCLIN-DEPENDENT KINASE ENZYMES | WARNER-LAMBERT COMPANY (US) | 2002-09-04 | — | — | EP | claimed |
| WO-2001038315-A1 | QUINAZOLINES AND THEIR USE FOR INHIBITING CYCLIN-DEPENDENT KINASE ENZYMES | WARNER-LAMBERT COMPANY (US) | 2001-05-31 | — | — | WO | claimed |
| US-6982260-B1 | Quinazolines and their use for inhibiting cyclin-dependent kinase enzymes | WARNER-LAMBERT COMPANY (US) | 2006-01-03 | — | — | US | disclosed |
| EP-1235815-A1 | QUINAZOLINES AND THEIR USE FOR INHIBITING CYCLIN-DEPENDENT KINASE ENZYMES | WARNER-LAMBERT COMPANY (US) | 2002-09-04 | — | — | EP | disclosed |
| WO-2001038315-A1 | QUINAZOLINES AND THEIR USE FOR INHIBITING CYCLIN-DEPENDENT KINASE ENZYMES | WARNER-LAMBERT COMPANY (US) | 2001-05-31 | — | — | WO | disclosed |