Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 16/20 | 0.62 |
| ▸ | CCND1 | P24385 | 15/20 | 0.62 |
| ▸ | CCNE1 | P24864 | 10/20 | 0.60 |
| ▸ | CDK2 | P24941 | 10/20 | 0.60 |
| ▸ | CDK1 | P06493 | 9/20 | 0.60 |
| ▸ | CCNB1 | P14635 | 8/20 | 0.60 |
| ▸ | FGFR4 | P22455 | 3/20 | 0.56 |
| ▸ | CCND2 | P30279 | 5/20 | 0.55 |
| ▸ | CCND3 | P30281 | 5/20 | 0.55 |
| ▸ | CCNE2 | O96020 | 3/20 | 0.55 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.55 |
| ▸ | CCNA1 | P78396 | 3/20 | 0.55 |
| ▸ | PKN1 | Q16512 | 2/20 | 0.55 |
| ▸ | PAK4 | O96013 | 1/20 | 0.55 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.55 |
| ▸ | SRC | P12931 | 2/20 | 0.55 |
| ▸ | KDR | P35968 | 2/20 | 0.55 |
| ▸ | AURKA | O14965 | 1/20 | 0.55 |
| ▸ | INSR | P06213 | 1/20 | 0.55 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6087900 | 0.89 | CDK4 (0.74) | CDK4CCND1CCNE1CDK2CDK1 | |
| SCHEMBL6086886 | 0.88 | CDK4 (0.75) | CDK4CCND1CCNE1CDK2CDK1 | |
| SCHEMBL6087132 | 0.87 | CDK4 (0.70) | CDK4CCND1CCNE1CDK2CDK1 | |
| SCHEMBL7465657 | 0.86 | CDK4 (0.56) | CDK4CCND1CCNE1CDK2CDK1 | |
| SCHEMBL6087241 | 0.86 | CDK4 (0.63) | CDK4CCND1CCNE1CDK2CDK1 | |
| SCHEMBL6087215 | 0.86 | CDK4 (0.64) | CDK4CCND1CCNE1CDK2CDK1 | |
| SCHEMBL6088670 | 0.85 | CDK4 (0.63) | CDK4CCND1CCNE1CDK2CDK1 | |
| SCHEMBL6090404 | 0.83 | CDK4 (0.57) | CDK4CCND1CCNE1CDK2CDK1 | |
| SCHEMBL6087511 | 0.82 | CDK4 (0.58) | CDK4CCND1CCNE1CDK2CDK1 | |
| SCHEMBL6088024 | 0.77 | CDK4 (1.00) | CDK4CCND1CCNE1CDK2CDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1235815-A1 | QUINAZOLINES AND THEIR USE FOR INHIBITING CYCLIN-DEPENDENT KINASE ENZYMES | WARNER-LAMBERT COMPANY (US) | 2002-09-04 | — | — | EP | claimed |
| WO-2001038315-A1 | QUINAZOLINES AND THEIR USE FOR INHIBITING CYCLIN-DEPENDENT KINASE ENZYMES | WARNER-LAMBERT COMPANY (US) | 2001-05-31 | — | — | WO | claimed |
| US-6982260-B1 | Quinazolines and their use for inhibiting cyclin-dependent kinase enzymes | WARNER-LAMBERT COMPANY (US) | 2006-01-03 | — | — | US | disclosed |