Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 13/20 | 0.64 |
| ▸ | CCND1 | P24385 | 12/20 | 0.64 |
| ▸ | CCND2 | P30279 | 2/20 | 0.58 |
| ▸ | CCND3 | P30281 | 2/20 | 0.58 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.58 |
| ▸ | MARK3 | P27448 | 1/20 | 0.58 |
| ▸ | MARK2 | Q7KZI7 | 1/20 | 0.58 |
| ▸ | MARK4 | Q96L34 | 1/20 | 0.58 |
| ▸ | NUAK2 | Q9H093 | 1/20 | 0.58 |
| ▸ | MARK1 | Q9P0L2 | 1/20 | 0.58 |
| ▸ | BRD4 | O60885 | 4/20 | 0.50 |
| ▸ | CDK1 | P06493 | 5/20 | 0.49 |
| ▸ | CCNE1 | P24864 | 5/20 | 0.49 |
| ▸ | CDK2 | P24941 | 5/20 | 0.49 |
| ▸ | CCNB1 | P14635 | 4/20 | 0.49 |
| ▸ | AURKA | O14965 | 1/20 | 0.49 |
| ▸ | INSR | P06213 | 1/20 | 0.49 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.49 |
| ▸ | SRC | P12931 | 1/20 | 0.49 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6087493 | 0.90 | CDK4 (0.79) | CDK4CCND1CCND2CCND3NUAK1 | |
| SCHEMBL6087954 | 0.89 | CDK4 (0.78) | CDK4CCND1CCND2CCND3NUAK1 | |
| SCHEMBL6087452 | 0.88 | CDK4 (0.65) | CDK4CCND1CCND2CCND3NUAK1 | |
| SCHEMBL7473526 | 0.88 | CDK4 (0.59) | CDK4CCND1CCND2CCND3NUAK1 | |
| SCHEMBL6090784 | 0.88 | CDK4 (0.75) | CDK4CCND1CCND2CCND3NUAK1 | |
| SCHEMBL6087241 | 0.86 | CDK4 (0.63) | CDK4CCND1CCND2CCND3NUAK1 | |
| SCHEMBL6088670 | 0.86 | CDK4 (0.63) | CDK4CCND1CCND2CCND3CDK1 | |
| SCHEMBL6086615 | 0.84 | CDK4 (0.62) | CDK4CCND1CCND2CCND3NUAK1 | |
| SCHEMBL6087490 | 0.83 | CDK4 (0.63) | CDK4CCND1CCND2CCND3NUAK1 | |
| SCHEMBL6087433 | 0.80 | CDK4 (0.53) | CDK4CCND1CCND2CCND3NUAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1235815-A1 | QUINAZOLINES AND THEIR USE FOR INHIBITING CYCLIN-DEPENDENT KINASE ENZYMES | WARNER-LAMBERT COMPANY (US) | 2002-09-04 | — | — | EP | claimed |
| WO-2001038315-A1 | QUINAZOLINES AND THEIR USE FOR INHIBITING CYCLIN-DEPENDENT KINASE ENZYMES | WARNER-LAMBERT COMPANY (US) | 2001-05-31 | — | — | WO | claimed |
| US-6982260-B1 | Quinazolines and their use for inhibiting cyclin-dependent kinase enzymes | WARNER-LAMBERT COMPANY (US) | 2006-01-03 | — | — | US | disclosed |