Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 13/20 | 0.46 |
| ▸ | CCND1 | P24385 | 11/20 | 0.46 |
| ▸ | CDK1 | P06493 | 5/20 | 0.46 |
| ▸ | CCNE1 | P24864 | 5/20 | 0.46 |
| ▸ | CDK2 | P24941 | 5/20 | 0.46 |
| ▸ | CCNB1 | P14635 | 4/20 | 0.46 |
| ▸ | CCND2 | P30279 | 4/20 | 0.46 |
| ▸ | CCND3 | P30281 | 4/20 | 0.46 |
| ▸ | CCNE2 | O96020 | 3/20 | 0.46 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.46 |
| ▸ | CCNA1 | P78396 | 3/20 | 0.46 |
| ▸ | CCNB2 | O95067 | 2/20 | 0.46 |
| ▸ | CCNB3 | Q8WWL7 | 2/20 | 0.46 |
| ▸ | SYK | P43405 | 3/20 | 0.45 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.43 |
| ▸ | AURKA | O14965 | 2/20 | 0.43 |
| ▸ | SRC | P12931 | 2/20 | 0.43 |
| ▸ | KDR | P35968 | 2/20 | 0.43 |
| ▸ | INSR | P06213 | 1/20 | 0.43 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6087037 | 0.92 | CDK4 (0.55) | CDK4CCND1CDK1CCNE1CDK2 | |
| SCHEMBL6086961 | 0.89 | SYK (0.55) | CDK4CCND1CCNE1CDK2CCND2 | |
| SCHEMBL6087887 | 0.89 | CDK4 (0.49) | CDK4CCND1CDK1CCNE1CDK2 | |
| SCHEMBL6087803 | 0.88 | CDK4 (0.42) | CDK4CCND1CDK1CCNE1CDK2 | |
| SCHEMBL7469937 | 0.87 | CDK4 (0.41) | CDK4CCND1CDK1CCNE1CDK2 | |
| SCHEMBL6089130 | 0.87 | CDK1 (0.54) | CDK4CCND1CDK1CCNE1CDK2 | |
| SCHEMBL6087383 | 0.87 | SYK (0.54) | CDK4CCND1CDK1CCNE1CDK2 | |
| SCHEMBL7462456 | 0.86 | SYK (0.43) | CDK4CCND1CDK1CCNE1CDK2 | |
| SCHEMBL7463354 | 0.86 | ERBB3 (0.41) | CDK4CCND1CDK1CCNE1CDK2 | |
| SCHEMBL6087039 | 0.85 | CDK4 (0.52) | CDK4CCND1CDK1CCNE1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6982260-B1 | Quinazolines and their use for inhibiting cyclin-dependent kinase enzymes | WARNER-LAMBERT COMPANY (US) | 2006-01-03 | — | — | US | disclosed |