Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 7/20 | 0.79 |
| ▸ | CCND1 | P24385 | 7/20 | 0.79 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.64 |
| ▸ | CDK2 | P24941 | 2/20 | 0.64 |
| ▸ | CCND2 | P30279 | 2/20 | 0.62 |
| ▸ | CCND3 | P30281 | 2/20 | 0.62 |
| ▸ | SYK | P43405 | 12/20 | 0.56 |
| ▸ | CDK1 | P06493 | 1/20 | 0.55 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.55 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6087001 | 0.91 | CDK4 (0.80) | CDK4CCND1CCNE1CDK2CCND2 | |
| SCHEMBL6087954 | 0.89 | CDK4 (0.78) | CDK4CCND1CCNE1CDK2CCND2 | |
| SCHEMBL6087452 | 0.89 | CDK4 (0.65) | CDK4CCND1CCNE1CDK2CCND2 | |
| SCHEMBL6090001 | 0.88 | CDK4 (1.00) | CDK4CCND1CCNE1CDK2CCND2 | |
| SCHEMBL6088101 | 0.88 | CDK4 (0.77) | CDK4CCND1CCNE1CDK2CCND2 | |
| SCHEMBL6087477 | 0.88 | CDK4 (0.77) | CDK4CCND1CCNE1CDK2CCND2 | |
| SCHEMBL6086856 | 0.87 | CDK4 (0.77) | CDK4CCND1CCNE1CDK2SYK | |
| SCHEMBL6088960 | 0.86 | CDK4 (0.95) | CDK4CCND1CCNE1CDK2CCND2 | |
| SCHEMBL6087502 | 0.86 | CDK4 (0.80) | CDK4CCND1CCNE1CDK2CCND2 | |
| SCHEMBL7469172 | 0.85 | CDK4 (0.59) | CDK4CCND1CCNE1CDK2CCND2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1235815-A1 | QUINAZOLINES AND THEIR USE FOR INHIBITING CYCLIN-DEPENDENT KINASE ENZYMES | WARNER-LAMBERT COMPANY (US) | 2002-09-04 | — | — | EP | claimed |
| WO-2001038315-A1 | QUINAZOLINES AND THEIR USE FOR INHIBITING CYCLIN-DEPENDENT KINASE ENZYMES | WARNER-LAMBERT COMPANY (US) | 2001-05-31 | — | — | WO | claimed |
| US-6982260-B1 | Quinazolines and their use for inhibiting cyclin-dependent kinase enzymes | WARNER-LAMBERT COMPANY (US) | 2006-01-03 | — | — | US | disclosed |
| EP-1235815-A1 | QUINAZOLINES AND THEIR USE FOR INHIBITING CYCLIN-DEPENDENT KINASE ENZYMES | WARNER-LAMBERT COMPANY (US) | 2002-09-04 | — | — | EP | disclosed |
| WO-2001038315-A1 | QUINAZOLINES AND THEIR USE FOR INHIBITING CYCLIN-DEPENDENT KINASE ENZYMES | WARNER-LAMBERT COMPANY (US) | 2001-05-31 | — | — | WO | disclosed |