Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 19/20 | 0.69 |
| ▸ | CCND1 | P24385 | 19/20 | 0.69 |
| ▸ | CCNE1 | P24864 | 14/20 | 0.69 |
| ▸ | CDK2 | P24941 | 14/20 | 0.69 |
| ▸ | CDK1 | P06493 | 11/20 | 0.69 |
| ▸ | CCNB1 | P14635 | 11/20 | 0.69 |
| ▸ | SUV39H2 | Q9H5I1 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6087337 | 0.90 | CDK4 (0.73) | CDK4CCND1CCNE1CDK2CDK1 | |
| SCHEMBL6087411 | 0.85 | CDK4 (0.80) | CDK4CCND1CCNE1CDK2CDK1 | |
| SCHEMBL6087444 | 0.82 | CDK4 (1.00) | CDK4CCND1CCNE1CDK2CDK1 | |
| SCHEMBL6088024 | 0.81 | CDK4 (1.00) | CDK4CCND1CCNE1CDK2CDK1 | |
| SCHEMBL6087349 | 0.80 | CDK4 (1.00) | CDK4CCND1CCNE1CDK2CDK1 | |
| SCHEMBL6088241 | 0.80 | CDK4 (1.00) | CDK4CCND1CCNE1CDK2CDK1 | |
| SCHEMBL6086509 | 0.80 | CDK4 (0.67) | CDK4CCND1CCNE1CDK2CDK1 | |
| SCHEMBL6086527 | 0.79 | CDK4 (1.00) | CDK4CCND1CCNE1CDK2CDK1 | |
| SCHEMBL6087555 | 0.79 | CDK4 (0.87) | CDK4CCND1CCNE1CDK2CDK1 | |
| SCHEMBL5515852 | 0.78 | SYK (0.52) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6982260-B1 | Quinazolines and their use for inhibiting cyclin-dependent kinase enzymes | WARNER-LAMBERT COMPANY (US) | 2006-01-03 | — | — | US | disclosed |