Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 4/20 | 0.40 |
| ▸ | SRC | P12931 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MPO | P05164 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | ALPI | P09923 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.37 |
| ▸ | XIAP | P98170 | 1/20 | 0.37 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6088290 | 1.00 | EGFR (0.40) | EGFRSRCKDM4EMEN1LMNA | |
| SCHEMBL6089510 | 0.94 | EGFR (0.36) | EGFRSRCKDM4EMEN1LMNA | |
| SCHEMBL6088846 | 0.94 | SLC7A5 (0.38) | EGFRSRCKDM4EMEN1LMNA | |
| SCHEMBL6088856 | 0.94 | SLC7A5 (0.38) | EGFRSRCKDM4EMEN1LMNA | |
| SCHEMBL6089496 | 0.94 | EGFR (0.36) | EGFRSRCKDM4EMEN1LMNA | |
| SCHEMBL7489562 | 0.84 | KDM4E (0.36) | EGFRSRCKDM4EPKMPARP1 | |
| SCHEMBL6089502 | 0.82 | KDM4E (0.37) | EGFRSRCKDM4EMEN1LMNA | |
| SCHEMBL6089497 | 0.82 | KDM4E (0.37) | EGFRSRCKDM4EMEN1LMNA | |
| SCHEMBL6089482 | 0.81 | EGFR (0.37) | EGFRSRCKDM4EMEN1LMNA | |
| SCHEMBL6089574 | 0.81 | SCN9A (0.37) | EGFRSRCKDM4EMEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7060822-B1 | 2-pyrazolin-5-ones | ABBOTT GMBH & CO. KG (DE) | 2006-06-13 | — | — | US | disclosed |