Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 4/20 | 0.49 |
| ▸ | JAK3 | P52333 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MMP2 | P08253 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | RELA | Q04206 | 1/20 | 0.40 |
| ▸ | PDPK1 | O15530 | 5/20 | 0.38 |
| ▸ | KDR | P35968 | 4/20 | 0.38 |
| ▸ | TLK2 | Q86UE8 | 4/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6088057 | 0.86 | PDPK1 (0.45) | PDGFRBJAK3SMN1; SMN2L3MBTL1ALDH1A1 | |
| SCHEMBL6091444 | 0.86 | TLK2 (0.46) | PDGFRBJAK3SMN1; SMN2L3MBTL1ALDH1A1 | |
| SCHEMBL6090438 | 0.85 | KDR (0.44) | PDGFRBJAK3SMN1; SMN2L3MBTL1ALDH1A1 | |
| SCHEMBL6089523 | 0.85 | PDGFRB (0.47) | PDGFRBJAK3SMN1; SMN2L3MBTL1ALDH1A1 | |
| SCHEMBL6091693 | 0.83 | TLK2 (0.48) | PDGFRBJAK3ALDH1A1PDPK1KDR | |
| SCHEMBL6089310 | 0.79 | KAT8 (0.48) | PDGFRBJAK3SMN1; SMN2L3MBTL1ALDH1A1 | |
| SCHEMBL6089305 | 0.79 | KAT8 (0.48) | PDGFRBJAK3SMN1; SMN2L3MBTL1ALDH1A1 | |
| SCHEMBL6088474 | 0.78 | RET (0.53) | PDGFRBSMN1; SMN2L3MBTL1ALDH1A1MEN1 | |
| SCHEMBL6089068 | 0.76 | PDGFRB (0.49) | PDGFRBJAK3SMN1; SMN2L3MBTL1ALDH1A1 | |
| SCHEMBL6091915 | 0.70 | PDPK1 (0.54) | PDGFRBJAK3SMN1; SMN2L3MBTL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1218373-A2 | 2-PYRAZOLIN-5-ONES AS TYROSINE KINASE INHIBITORS | BASF AKTIENGESELLSCHAFT (DE) | 2002-07-03 | — | — | EP | claimed |
| WO-2001009121-A2 | 2-PYRAZOLIN-5-ONES_AS TYROSINE KINASE INHIBITORS | BASF AKTIENGESELLSCHAFT (DE) | 2001-02-08 | — | — | WO | claimed |
| US-7060822-B1 | 2-pyrazolin-5-ones | ABBOTT GMBH & CO. KG (DE) | 2006-06-13 | — | — | US | disclosed |
| EP-1218373-A2 | 2-PYRAZOLIN-5-ONES AS TYROSINE KINASE INHIBITORS | BASF AKTIENGESELLSCHAFT (DE) | 2002-07-03 | — | — | EP | disclosed |
| WO-2001009121-A2 | 2-PYRAZOLIN-5-ONES_AS TYROSINE KINASE INHIBITORS | BASF AKTIENGESELLSCHAFT (DE) | 2001-02-08 | — | — | WO | disclosed |