Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 11/20 | 0.45 |
| ▸ | CDK4 | P11802 | 6/20 | 0.45 |
| ▸ | CCNT1 | O60563 | 5/20 | 0.45 |
| ▸ | CDK1 | P06493 | 5/20 | 0.45 |
| ▸ | CCNB1 | P14635 | 5/20 | 0.45 |
| ▸ | CCND1 | P24385 | 5/20 | 0.45 |
| ▸ | CCNE1 | P24864 | 5/20 | 0.45 |
| ▸ | CDK9 | P50750 | 5/20 | 0.45 |
| ▸ | CDK7 | P50613 | 4/20 | 0.45 |
| ▸ | CCNH | P51946 | 4/20 | 0.45 |
| ▸ | IGF1R | P08069 | 6/20 | 0.45 |
| ▸ | CCNA2 | P20248 | 6/20 | 0.43 |
| ▸ | PLK1 | P53350 | 4/20 | 0.41 |
| ▸ | AURKA | O14965 | 3/20 | 0.41 |
| ▸ | CCNA1 | P78396 | 3/20 | 0.41 |
| ▸ | IKBKB | O14920 | 2/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | CCND3 | P30281 | 1/20 | 0.39 |
| ▸ | TTK | P33981 | 1/20 | 0.39 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6086771 | 0.89 | CDK2 (0.56) | CDK2CDK4CCNT1CDK1CCNB1 | |
| SCHEMBL6087697 | 0.84 | IKBKB (0.46) | CDK2CDK4CCNT1CDK1CCNB1 | |
| SCHEMBL6086798 | 0.82 | IGF1R (0.50) | CDK2CDK4CCNT1CDK1CCNB1 | |
| SCHEMBL6086206 | 0.80 | CDK2 (0.43) | CDK2CDK4CCNT1CDK1CCNB1 | |
| SCHEMBL6087509 | 0.80 | IGF1R (0.46) | CDK2CDK4CCNT1CDK1CCNB1 | |
| SCHEMBL6086788 | 0.80 | CDK4 (0.57) | CDK2CDK4CCNT1CDK1CCNB1 | |
| SCHEMBL6086925 | 0.78 | IGF1R (0.46) | CDK2CDK4CCNT1CDK1CCNB1 | |
| SCHEMBL6087971 | 0.77 | ALK (0.57) | CDK2CDK4CCNT1CDK1CCNB1 | |
| SCHEMBL6087308 | 0.77 | CDK2 (0.54) | CDK2CDK4CCNT1CDK1CCNB1 | |
| SCHEMBL6086413 | 0.75 | SYK (0.53) | CDK2CDK4CDK1CCNB1CCND1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1235815-A1 | QUINAZOLINES AND THEIR USE FOR INHIBITING CYCLIN-DEPENDENT KINASE ENZYMES | WARNER-LAMBERT COMPANY (US) | 2002-09-04 | — | — | EP | claimed |
| WO-2001038315-A1 | QUINAZOLINES AND THEIR USE FOR INHIBITING CYCLIN-DEPENDENT KINASE ENZYMES | WARNER-LAMBERT COMPANY (US) | 2001-05-31 | — | — | WO | claimed |
| US-6982260-B1 | Quinazolines and their use for inhibiting cyclin-dependent kinase enzymes | WARNER-LAMBERT COMPANY (US) | 2006-01-03 | — | — | US | disclosed |
| EP-1235815-A1 | QUINAZOLINES AND THEIR USE FOR INHIBITING CYCLIN-DEPENDENT KINASE ENZYMES | WARNER-LAMBERT COMPANY (US) | 2002-09-04 | — | — | EP | disclosed |
| WO-2001038315-A1 | QUINAZOLINES AND THEIR USE FOR INHIBITING CYCLIN-DEPENDENT KINASE ENZYMES | WARNER-LAMBERT COMPANY (US) | 2001-05-31 | — | — | WO | disclosed |