Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLK2 | Q86UE8 | 3/20 | 0.49 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.49 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.42 |
| ▸ | FLT3 | P36888 | 5/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 2/20 | 0.40 |
| ▸ | KIT | P10721 | 1/20 | 0.39 |
| ▸ | FLT4 | P35916 | 1/20 | 0.39 |
| ▸ | KAT8 | Q9H7Z6 | 1/20 | 0.38 |
| ▸ | HTR1B | P28222 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6089463 | 1.00 | TLK2 (0.49) | TLK2PDPK1NTRK1FLT3MAOA | |
| SCHEMBL6090940 | 0.88 | TLK2 (0.49) | TLK2PDPK1NTRK1FLT3MAOA | |
| SCHEMBL6090945 | 0.88 | TLK2 (0.49) | TLK2PDPK1NTRK1FLT3MAOA | |
| SCHEMBL6091220 | 0.85 | TLK2 (0.50) | TLK2PDPK1NTRK1FLT3AURKB | |
| SCHEMBL6091218 | 0.85 | TLK2 (0.50) | TLK2PDPK1NTRK1FLT3AURKB | |
| SCHEMBL6091243 | 0.82 | KAT8 (0.52) | TLK2PDPK1NTRK1FLT3AURKB | |
| SCHEMBL6091248 | 0.82 | KAT8 (0.52) | TLK2PDPK1NTRK1FLT3AURKB | |
| SCHEMBL6091697 | 0.80 | TLK2 (0.48) | TLK2PDPK1NTRK1FLT3MAOA | |
| SCHEMBL6090294 | 0.79 | PDPK1 (0.46) | TLK2PDPK1NTRK1FLT3AURKB | |
| SCHEMBL6090287 | 0.79 | PDPK1 (0.46) | TLK2PDPK1NTRK1FLT3AURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1218373-A2 | 2-PYRAZOLIN-5-ONES AS TYROSINE KINASE INHIBITORS | BASF AKTIENGESELLSCHAFT (DE) | 2002-07-03 | — | — | EP | claimed |
| WO-2001009121-A2 | 2-PYRAZOLIN-5-ONES_AS TYROSINE KINASE INHIBITORS | BASF AKTIENGESELLSCHAFT (DE) | 2001-02-08 | — | — | WO | claimed |
| US-7060822-B1 | 2-pyrazolin-5-ones | ABBOTT GMBH & CO. KG (DE) | 2006-06-13 | — | — | US | disclosed |
| EP-1218373-A2 | 2-PYRAZOLIN-5-ONES AS TYROSINE KINASE INHIBITORS | BASF AKTIENGESELLSCHAFT (DE) | 2002-07-03 | — | — | EP | disclosed |
| WO-2001009121-A2 | 2-PYRAZOLIN-5-ONES_AS TYROSINE KINASE INHIBITORS | BASF AKTIENGESELLSCHAFT (DE) | 2001-02-08 | — | — | WO | disclosed |