Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 2/20 | 0.39 |
| ▸ | KDR | P35968 | 4/20 | 0.38 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.38 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.32 |
| ▸ | LCK | P06239 | 2/20 | 0.31 |
| ▸ | FYN | P06241 | 2/20 | 0.31 |
| ▸ | YES1 | P07947 | 2/20 | 0.31 |
| ▸ | SRC | P12931 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6089549 | 1.00 | CHEK1 (0.39) | CHEK1KDRPDGFRBFGFR1HRH3 | |
| SCHEMBL6090309 | 0.94 | CHEK1 (0.40) | CHEK1KDRPDGFRBFGFR1 | |
| SCHEMBL6090312 | 0.94 | CHEK1 (0.40) | CHEK1KDRPDGFRBFGFR1 | |
| SCHEMBL6099973 | 0.88 | CHEK1 (0.36) | CHEK1KDRPDGFRBFGFR1 | |
| SCHEMBL6099975 | 0.88 | CHEK1 (0.36) | CHEK1KDRPDGFRBFGFR1 | |
| SCHEMBL6091257 | 0.87 | PDGFRB (0.36) | CHEK1KDRPDGFRBFGFR1HRH3 | |
| SCHEMBL6091252 | 0.87 | PDGFRB (0.36) | CHEK1KDRPDGFRBFGFR1HRH3 | |
| SCHEMBL6088659 | 0.85 | PDGFRB (0.39) | CHEK1KDRPDGFRBFGFR1HRH3 | |
| SCHEMBL6088656 | 0.85 | PDGFRB (0.39) | CHEK1KDRPDGFRBFGFR1HRH3 | |
| SCHEMBL6090944 | 0.85 | KDR (0.39) | CHEK1KDRPDGFRBFGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7060822-B1 | 2-pyrazolin-5-ones | ABBOTT GMBH & CO. KG (DE) | 2006-06-13 | — | — | US | disclosed |