Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 13/20 | 0.73 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.73 |
| ▸ | ALK | Q9UM73 | 3/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
| ▸ | FGFR1 | P11362 | 8/20 | 0.38 |
| ▸ | PDGFRB | P09619 | 8/20 | 0.38 |
| ▸ | RET | P07949 | 3/20 | 0.38 |
| ▸ | FLT3 | P36888 | 3/20 | 0.38 |
| ▸ | PRKAA1 | Q13131 | 3/20 | 0.38 |
| ▸ | AURKA | O14965 | 2/20 | 0.38 |
| ▸ | FLT1 | P17948 | 2/20 | 0.38 |
| ▸ | MAP4K2 | Q12851 | 2/20 | 0.38 |
| ▸ | STK3 | Q13188 | 2/20 | 0.38 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.38 |
| ▸ | GAK | O14976 | 1/20 | 0.38 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.38 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.38 |
| ▸ | LATS1 | O95835 | 1/20 | 0.38 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.38 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6088845 | 0.91 | KDR (0.59) | KDRCHEK1ALKIDO1FGFR1 | |
| SCHEMBL6088839 | 0.91 | KDR (0.59) | KDRCHEK1ALKIDO1FGFR1 | |
| SCHEMBL6088446 | 0.89 | KDR (0.69) | KDRCHEK1ALKFGFR1PDGFRB | |
| SCHEMBL6088440 | 0.89 | KDR (0.69) | KDRCHEK1ALKFGFR1PDGFRB | |
| SCHEMBL6089261 | 0.89 | KDR (0.72) | KDRCHEK1ALKFGFR1PDGFRB | |
| SCHEMBL6089891 | 0.89 | KDR (0.72) | KDRCHEK1ALKFGFR1PDGFRB | |
| SCHEMBL6087930 | 0.85 | KDR (0.52) | KDRCHEK1ALKFGFR1PDGFRB | |
| SCHEMBL6087925 | 0.85 | KDR (0.52) | KDRCHEK1ALKFGFR1PDGFRB | |
| SCHEMBL6090073 | 0.84 | KDR (0.71) | KDRCHEK1ALKFGFR1PDGFRB | |
| SCHEMBL6092922 | 0.84 | KDR (0.71) | KDRCHEK1ALKFGFR1PDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7060822-B1 | 2-pyrazolin-5-ones | ABBOTT GMBH & CO. KG (DE) | 2006-06-13 | — | — | US | disclosed |