Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 12/20 | 0.56 |
| ▸ | AURKB | Q96GD4 | 7/20 | 0.52 |
| ▸ | KDR | P35968 | 6/20 | 0.52 |
| ▸ | EGFR | P00533 | 4/20 | 0.52 |
| ▸ | BRAF | P15056 | 2/20 | 0.52 |
| ▸ | FLT4 | P35916 | 4/20 | 0.49 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.49 |
| ▸ | FLT1 | P17948 | 3/20 | 0.49 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.49 |
| ▸ | CDK1 | P06493 | 1/20 | 0.49 |
| ▸ | FLT3 | P36888 | 2/20 | 0.49 |
| ▸ | MET | P08581 | 2/20 | 0.49 |
| ▸ | PLK4 | O00444 | 1/20 | 0.49 |
| ▸ | CIT | O14578 | 1/20 | 0.49 |
| ▸ | MUSK | O15146 | 1/20 | 0.49 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.49 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.49 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.49 |
| ▸ | STK10 | O94804 | 1/20 | 0.49 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6030625 | 0.99 | AURKA (0.56) | AURKAAURKBKDREGFRBRAF | |
| SCHEMBL6028491 | 0.94 | AURKA (0.55) | AURKAAURKBKDREGFRBRAF | |
| SCHEMBL6027522 | 0.94 | AURKA (0.57) | AURKAAURKBKDREGFRBRAF | |
| SCHEMBL6027774 | 0.94 | AURKA (0.56) | AURKAAURKBKDREGFRBRAF | |
| SCHEMBL6026562 | 0.94 | KDR (0.60) | AURKAAURKBKDREGFRBRAF | |
| SCHEMBL6028435 | 0.93 | AURKA (0.56) | AURKAAURKBKDREGFRBRAF | |
| SCHEMBL6029185 | 0.92 | AURKA (0.59) | AURKAAURKBKDREGFRBRAF | |
| SCHEMBL6031396 | 0.91 | AURKA (0.55) | AURKAAURKBKDREGFRBRAF | |
| SCHEMBL6026358 | 0.90 | PDGFRB (0.53) | AURKAAURKBKDREGFRBRAF | |
| SCHEMBL6027367 | 0.89 | AURKA (0.73) | AURKAAURKBKDREGFRFLT4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060178382-A1 | Chinazoline derivatives as aurora kinase inhibitors | ASTRAZENECA AB (SE) | 2006-08-10 | — | — | US | claimed |
| US-20060178382-A1 | Chinazoline derivatives as aurora kinase inhibitors | ASTRAZENECA AB (SE) | 2006-08-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060178382-A1 | Chinazoline derivatives as aurora kinase inhibitors | AURKA, AURKC, AURKB | AURKA 1/4885AURKB 3/4885KDR 1914/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.