Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 14/20 | 0.51 |
| ▸ | SRC | P12931 | 12/20 | 0.51 |
| ▸ | FGFR1 | P11362 | 9/20 | 0.51 |
| ▸ | LCK | P06239 | 6/20 | 0.51 |
| ▸ | FYN | P06241 | 6/20 | 0.51 |
| ▸ | YES1 | P07947 | 6/20 | 0.51 |
| ▸ | PDGFRB | P09619 | 9/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | GLA | P06280 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | CASP1 | P29466 | 2/20 | 0.35 |
| ▸ | CASP7 | P55210 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | PARP1 | P09874 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | KIT | P10721 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6090525 | 1.00 | KDR (0.51) | KDRSRCFGFR1LCKFYN | |
| SCHEMBL6089175 | 0.93 | SRC (0.42) | KDRSRCFGFR1LCKFYN | |
| SCHEMBL6089182 | 0.93 | SRC (0.42) | KDRSRCFGFR1LCKFYN | |
| SCHEMBL6093052 | 0.92 | SRC (0.41) | KDRSRCFGFR1LCKFYN | |
| SCHEMBL6093046 | 0.92 | SRC (0.41) | KDRSRCFGFR1LCKFYN | |
| SCHEMBL6089569 | 0.90 | SRC (0.49) | KDRSRCFGFR1LCKFYN | |
| SCHEMBL6089561 | 0.90 | SRC (0.49) | KDRSRCFGFR1LCKFYN | |
| SCHEMBL6091121 | 0.90 | SRC (0.43) | KDRSRCFGFR1LCKFYN | |
| SCHEMBL6091112 | 0.90 | SRC (0.43) | KDRSRCFGFR1LCKFYN | |
| SCHEMBL6089694 | 0.88 | KDR (0.50) | KDRSRCFGFR1LCKFYN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7060822-B1 | 2-pyrazolin-5-ones | ABBOTT GMBH & CO. KG (DE) | 2006-06-13 | — | — | US | disclosed |