Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.41 |
| ▸ | KDR | P35968 | 5/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.35 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.35 |
| ▸ | LCK | P06239 | 2/20 | 0.34 |
| ▸ | FYN | P06241 | 2/20 | 0.34 |
| ▸ | YES1 | P07947 | 2/20 | 0.34 |
| ▸ | SRC | P12931 | 2/20 | 0.34 |
| ▸ | MET | P08581 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | PARP1 | P09874 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | ABL1 | P00519 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6090807 | 1.00 | KDM4E (0.43) | KDM4EALDH1A1CHEK1KDRHSD17B10 | |
| SCHEMBL6089313 | 0.87 | CHEK1 (0.41) | KDM4EALDH1A1CHEK1KDRHSD17B10 | |
| SCHEMBL6089318 | 0.87 | CHEK1 (0.41) | KDM4EALDH1A1CHEK1KDRHSD17B10 | |
| SCHEMBL6089732 | 0.81 | SRC (0.53) | KDM4EALDH1A1KDRHSD17B10FGFR1 | |
| SCHEMBL6089741 | 0.81 | SRC (0.53) | KDM4EALDH1A1KDRHSD17B10FGFR1 | |
| SCHEMBL6091725 | 0.81 | CHEK1 (0.42) | KDM4EALDH1A1CHEK1KDRHSD17B10 | |
| SCHEMBL6091728 | 0.81 | CHEK1 (0.42) | KDM4EALDH1A1CHEK1KDRHSD17B10 | |
| SCHEMBL6088946 | 0.80 | KDR (0.44) | KDM4EALDH1A1CHEK1KDRHSD17B10 | |
| SCHEMBL6088933 | 0.80 | KDR (0.44) | KDM4EALDH1A1CHEK1KDRHSD17B10 | |
| SCHEMBL6091989 | 0.79 | CHEK1 (0.47) | KDM4EALDH1A1CHEK1KDRHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7060822-B1 | 2-pyrazolin-5-ones | ABBOTT GMBH & CO. KG (DE) | 2006-06-13 | — | — | US | disclosed |