Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 11/20 | 0.56 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.44 |
| ▸ | RAF1 | P04049 | 5/20 | 0.43 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.43 |
| ▸ | LCK | P06239 | 2/20 | 0.40 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.38 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.38 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.38 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.38 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.38 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.38 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.38 |
| ▸ | MAP1LC3B | Q9GZQ8 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.38 |
| ▸ | ARAF | P10398 | 1/20 | 0.38 |
| ▸ | PIM1 | P11309 | 1/20 | 0.38 |
| ▸ | BRAF | P15056 | 1/20 | 0.38 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.38 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6090862 | 1.00 | KDR (0.56) | KDRCHEK1RAF1PIK3C3LCK | |
| SCHEMBL6088114 | 0.82 | RAF1 (0.44) | KDRRAF1PIK3C3LCKPSEN1 | |
| SCHEMBL6088120 | 0.82 | RAF1 (0.44) | KDRRAF1PIK3C3LCKPSEN1 | |
| SCHEMBL6089459 | 0.80 | RAF1 (0.49) | RAF1PIK3C3LCKPSEN1PSEN2 | |
| SCHEMBL6089469 | 0.80 | RAF1 (0.49) | RAF1PIK3C3LCKPSEN1PSEN2 | |
| SCHEMBL6089597 | 0.80 | RAF1 (0.61) | KDRRAF1PIK3C3LCKPSEN1 | |
| SCHEMBL6089601 | 0.80 | RAF1 (0.61) | KDRRAF1PIK3C3LCKPSEN1 | |
| SCHEMBL6089708 | 0.79 | RAF1 (0.46) | RAF1PIK3C3LCKPSEN1PSEN2 | |
| SCHEMBL6089715 | 0.79 | RAF1 (0.46) | RAF1PIK3C3LCKPSEN1PSEN2 | |
| SCHEMBL6089988 | 0.79 | RAF1 (0.48) | RAF1PIK3C3LCKPSEN1PSEN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7060822-B1 | 2-pyrazolin-5-ones | ABBOTT GMBH & CO. KG (DE) | 2006-06-13 | — | — | US | disclosed |