Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 15/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.35 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.35 |
| ▸ | KDR | P35968 | 3/20 | 0.35 |
| ▸ | LCK | P06239 | 2/20 | 0.35 |
| ▸ | FYN | P06241 | 2/20 | 0.35 |
| ▸ | YES1 | P07947 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | HPGD | P15428 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | GLA | P06280 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | PPARG | P37231 | 1/20 | 0.32 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14560398 | 0.84 | SRC (0.47) | SRCPDGFRBFGFR1KDRLCK | |
| SCHEMBL6405511 | 0.82 | SRC (0.56) | SRCPDGFRBFGFR1KDRLCK | |
| SCHEMBL6696760 | 0.81 | SRC (0.55) | SRCPDGFRBFGFR1KDRLCK | |
| SCHEMBL14560397 | 0.77 | SRC (0.41) | SRCPDGFRBFGFR1KDRLCK | |
| SCHEMBL6405608 | 0.74 | SRC (0.44) | SRCPDGFRBFGFR1KDRLCK | |
| SCHEMBL14560400 | 0.73 | SRC (0.38) | SRCPDGFRBFGFR1KDRLCK | |
| SCHEMBL6797512 | 0.73 | SRC (0.39) | SRCPDGFRBFGFR1KDRLCK | |
| SCHEMBL6692238 | 0.72 | SRC (0.38) | SRCPDGFRBFGFR1KDRLCK | |
| SCHEMBL5829815 | 0.72 | SRC (0.55) | SRCPDGFRBFGFR1KDRLCK | |
| SCHEMBL14560396 | 0.72 | SRC (0.47) | SRCPDGFRBFGFR1KDRLCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7060822-B1 | 2-pyrazolin-5-ones | ABBOTT GMBH & CO. KG (DE) | 2006-06-13 | — | — | US | disclosed |
| EP-1218373-A2 | 2-PYRAZOLIN-5-ONES AS TYROSINE KINASE INHIBITORS | BASF AKTIENGESELLSCHAFT (DE) | 2002-07-03 | — | — | EP | disclosed |
| WO-2001009121-A2 | 2-PYRAZOLIN-5-ONES_AS TYROSINE KINASE INHIBITORS | BASF AKTIENGESELLSCHAFT (DE) | 2001-02-08 | — | — | WO | disclosed |