Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 16/20 | 0.56 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.44 |
| ▸ | JAK3 | P52333 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6091002 | 1.00 | KDR (0.56) | KDRCHEK1JAK3 | |
| SCHEMBL6088961 | 0.86 | KDR (0.56) | KDRCHEK1JAK3 | |
| SCHEMBL6088970 | 0.86 | KDR (0.56) | KDRCHEK1JAK3 | |
| SCHEMBL6088156 | 0.83 | KDR (0.53) | KDRCHEK1 | |
| SCHEMBL6088145 | 0.83 | KDR (0.53) | KDRCHEK1 | |
| SCHEMBL6091055 | 0.80 | ALK (0.41) | KDRJAK3 | |
| SCHEMBL6091052 | 0.80 | ALK (0.41) | KDRJAK3 | |
| SCHEMBL6089300 | 0.80 | KDR (0.57) | KDRCHEK1 | |
| SCHEMBL6089311 | 0.80 | KDR (0.57) | KDRCHEK1 | |
| SCHEMBL6090173 | 0.78 | KDR (0.55) | KDRCHEK1JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7060822-B1 | 2-pyrazolin-5-ones | ABBOTT GMBH & CO. KG (DE) | 2006-06-13 | — | — | US | disclosed |