Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 3/20 | 0.43 |
| ▸ | KDR | P35968 | 5/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.37 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | AURKA | O14965 | 2/20 | 0.31 |
| ▸ | RET | P07949 | 2/20 | 0.31 |
| ▸ | FLT1 | P17948 | 2/20 | 0.31 |
| ▸ | FLT3 | P36888 | 2/20 | 0.31 |
| ▸ | MAP4K2 | Q12851 | 2/20 | 0.31 |
| ▸ | STK3 | Q13188 | 2/20 | 0.31 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6091081 | 1.00 | CHEK1 (0.43) | CHEK1KDRFGFR1PDGFRBKMT2A | |
| SCHEMBL6091725 | 0.90 | CHEK1 (0.42) | CHEK1KDRFGFR1PDGFRBHSD17B10 | |
| SCHEMBL6091728 | 0.90 | CHEK1 (0.42) | CHEK1KDRFGFR1PDGFRBHSD17B10 | |
| SCHEMBL6099973 | 0.89 | CHEK1 (0.36) | CHEK1KDRFGFR1PDGFRBKMT2A | |
| SCHEMBL6099975 | 0.89 | CHEK1 (0.36) | CHEK1KDRFGFR1PDGFRBKMT2A | |
| SCHEMBL6099989 | 0.87 | CHEK1 (0.35) | CHEK1KMT2AHSD17B10ALOX15MEN1 | |
| SCHEMBL6099985 | 0.87 | CHEK1 (0.35) | CHEK1KMT2AHSD17B10ALOX15MEN1 | |
| SCHEMBL6090679 | 0.83 | CHEK1 (0.49) | CHEK1KDRFGFR1PDGFRBAURKA | |
| SCHEMBL6089388 | 0.82 | CHEK1 (0.51) | CHEK1KDRFGFR1PDGFRBAURKA | |
| SCHEMBL6089384 | 0.82 | CHEK1 (0.51) | CHEK1KDRFGFR1PDGFRBAURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7060822-B1 | 2-pyrazolin-5-ones | ABBOTT GMBH & CO. KG (DE) | 2006-06-13 | — | — | US | disclosed |
| EP-1218373-A2 | 2-PYRAZOLIN-5-ONES AS TYROSINE KINASE INHIBITORS | BASF AKTIENGESELLSCHAFT (DE) | 2002-07-03 | — | — | EP | disclosed |
| WO-2001009121-A2 | 2-PYRAZOLIN-5-ONES_AS TYROSINE KINASE INHIBITORS | BASF AKTIENGESELLSCHAFT (DE) | 2001-02-08 | — | — | WO | disclosed |