Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 16/20 | 0.75 |
| ▸ | CHEK1 | O14757 | 4/20 | 0.75 |
| ▸ | PRKAA1 | Q13131 | 10/20 | 0.37 |
| ▸ | PDGFRB | P09619 | 9/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 8/20 | 0.37 |
| ▸ | PRKAA2 | P54646 | 7/20 | 0.37 |
| ▸ | RET | P07949 | 4/20 | 0.36 |
| ▸ | FLT3 | P36888 | 4/20 | 0.36 |
| ▸ | STK3 | Q13188 | 4/20 | 0.36 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.36 |
| ▸ | AURKA | O14965 | 3/20 | 0.36 |
| ▸ | FLT1 | P17948 | 3/20 | 0.36 |
| ▸ | MAP4K2 | Q12851 | 3/20 | 0.36 |
| ▸ | RPS6KA5 | O75582 | 3/20 | 0.36 |
| ▸ | RPS6KA4 | O75676 | 3/20 | 0.36 |
| ▸ | MAP2K2 | P36507 | 3/20 | 0.36 |
| ▸ | MAP2K1 | Q02750 | 3/20 | 0.36 |
| ▸ | PLK4 | O00444 | 3/20 | 0.36 |
| ▸ | PDPK1 | O15530 | 3/20 | 0.36 |
| ▸ | DAPK3 | O43293 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6088787 | 1.00 | KDR (0.75) | KDRCHEK1PRKAA1PDGFRBFGFR1 | |
| SCHEMBL6091189 | 0.91 | KDR (0.61) | KDRCHEK1PRKAA1PDGFRBFGFR1 | |
| SCHEMBL6091182 | 0.91 | KDR (0.61) | KDRCHEK1PRKAA1PDGFRBFGFR1 | |
| SCHEMBL6092728 | 0.87 | KDR (0.58) | KDRCHEK1PRKAA1PDGFRBFGFR1 | |
| SCHEMBL6088025 | 0.86 | KDR (1.00) | KDRCHEK1PRKAA1PDGFRBFGFR1 | |
| SCHEMBL6088007 | 0.86 | KDR (1.00) | KDRCHEK1PRKAA1PDGFRBFGFR1 | |
| SCHEMBL6088896 | 0.85 | KDR (0.55) | KDRCHEK1PRKAA1PDGFRBFGFR1 | |
| SCHEMBL6088895 | 0.85 | KDR (0.55) | KDRCHEK1PRKAA1PDGFRBFGFR1 | |
| SCHEMBL6092304 | 0.85 | KDR (0.55) | KDRCHEK1PRKAA1PDGFRBFGFR1 | |
| SCHEMBL6092309 | 0.85 | KDR (0.55) | KDRCHEK1PRKAA1PDGFRBFGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7060822-B1 | 2-pyrazolin-5-ones | ABBOTT GMBH & CO. KG (DE) | 2006-06-13 | — | — | US | disclosed |
| EP-1218373-A2 | 2-PYRAZOLIN-5-ONES AS TYROSINE KINASE INHIBITORS | BASF AKTIENGESELLSCHAFT (DE) | 2002-07-03 | — | — | EP | disclosed |
| WO-2001009121-A2 | 2-PYRAZOLIN-5-ONES_AS TYROSINE KINASE INHIBITORS | BASF AKTIENGESELLSCHAFT (DE) | 2001-02-08 | — | — | WO | disclosed |