Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 15/20 | 0.57 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.57 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.32 |
| ▸ | AURKA | O14965 | 1/20 | 0.31 |
| ▸ | GAK | O14976 | 1/20 | 0.31 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.31 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.31 |
| ▸ | LATS1 | O95835 | 1/20 | 0.31 |
| ▸ | RET | P07949 | 1/20 | 0.31 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.31 |
| ▸ | FLT1 | P17948 | 1/20 | 0.31 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.31 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.31 |
| ▸ | FLT3 | P36888 | 1/20 | 0.31 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.31 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.31 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6089389 | 0.93 | KDR (0.57) | KDRCHEK1ALKPDGFRB | |
| SCHEMBL6092746 | 0.92 | KDR (0.61) | KDRCHEK1 | |
| SCHEMBL6090930 | 0.91 | KDR (0.58) | KDRCHEK1ALKALDH1A1LMNA | |
| SCHEMBL6090913 | 0.91 | KDR (0.58) | KDRCHEK1ALKALDH1A1LMNA | |
| SCHEMBL6090162 | 0.90 | KDR (0.58) | KDRCHEK1 | |
| SCHEMBL6088910 | 0.90 | KDR (0.54) | KDRCHEK1PDGFRBFGFR1ZAP70 | |
| SCHEMBL6089861 | 0.88 | KDR (0.53) | KDRCHEK1 | |
| SCHEMBL6088035 | 0.86 | KDR (0.54) | KDRCHEK1 | |
| SCHEMBL6092401 | 0.86 | KDR (0.61) | KDRCHEK1PDGFRB | |
| SCHEMBL6088201 | 0.86 | KDR (0.59) | KDRCHEK1ALKALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7060822-B1 | 2-pyrazolin-5-ones | ABBOTT GMBH & CO. KG (DE) | 2006-06-13 | — | — | US | disclosed |