Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 6/20 | 0.44 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.44 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.32 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.31 |
| ▸ | EGFR | P00533 | 1/20 | 0.30 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.30 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.30 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.30 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6091500 | 1.00 | KDR (0.44) | KDRCHEK1ADORA2BPDGFRBEGFR | |
| SCHEMBL6090045 | 0.89 | KDR (0.53) | KDRCHEK1ADORA2BPDGFRBEGFR | |
| SCHEMBL6090039 | 0.89 | KDR (0.53) | KDRCHEK1ADORA2BPDGFRBEGFR | |
| SCHEMBL6089781 | 0.84 | KDR (0.39) | KDRCHEK1 | |
| SCHEMBL6089786 | 0.84 | KDR (0.39) | KDRCHEK1 | |
| SCHEMBL6090718 | 0.84 | KDR (0.43) | KDRCHEK1ADORA2B | |
| SCHEMBL6090712 | 0.84 | KDR (0.43) | KDRCHEK1ADORA2B | |
| SCHEMBL6087913 | 0.84 | KDR (0.48) | KDRCHEK1PDGFRBFGFR1PRKAA2 | |
| SCHEMBL6087910 | 0.84 | KDR (0.48) | KDRCHEK1PDGFRBFGFR1PRKAA2 | |
| SCHEMBL6092238 | 0.83 | KDR (0.49) | KDRCHEK1PDGFRBFGFR1PRKAA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7060822-B1 | 2-pyrazolin-5-ones | ABBOTT GMBH & CO. KG (DE) | 2006-06-13 | — | — | US | disclosed |