Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 6/20 | 0.47 |
| ▸ | PDGFRB | P09619 | 6/20 | 0.47 |
| ▸ | PDPK1 | O15530 | 6/20 | 0.47 |
| ▸ | RET | P07949 | 5/20 | 0.47 |
| ▸ | FLT3 | P36888 | 4/20 | 0.47 |
| ▸ | PRKD3 | O94806 | 3/20 | 0.47 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.47 |
| ▸ | ALK | Q9UM73 | 3/20 | 0.47 |
| ▸ | JAK3 | P52333 | 2/20 | 0.47 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.47 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.47 |
| ▸ | LCK | P06239 | 2/20 | 0.47 |
| ▸ | FYN | P06241 | 2/20 | 0.47 |
| ▸ | CSF1R | P07333 | 2/20 | 0.47 |
| ▸ | LTK | P29376 | 2/20 | 0.47 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.47 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.47 |
| ▸ | CDK7 | P50613 | 2/20 | 0.47 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.47 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6092088 | 1.00 | KDR (0.47) | KDRPDGFRBPDPK1RETFLT3 | |
| SCHEMBL6091361 | 0.84 | NTRK1 (0.59) | KDRPDGFRBRETFLT3PRKD3 | |
| SCHEMBL6091355 | 0.84 | NTRK1 (0.59) | KDRPDGFRBRETFLT3PRKD3 | |
| SCHEMBL6092365 | 0.77 | PDPK1 (0.50) | KDRPDGFRBPDPK1RETFLT3 | |
| SCHEMBL6092360 | 0.77 | PDPK1 (0.50) | KDRPDGFRBPDPK1RETFLT3 | |
| SCHEMBL6089951 | 0.77 | NTRK1 (0.53) | KDRPDGFRBRETFLT3PRKD3 | |
| SCHEMBL6089945 | 0.77 | NTRK1 (0.53) | KDRPDGFRBRETFLT3PRKD3 | |
| SCHEMBL6855898 | 0.76 | KDR (0.65) | KDRPDGFRBPDPK1RETFLT3 | |
| SCHEMBL6855894 | 0.76 | KDR (0.65) | KDRPDGFRBPDPK1RETFLT3 | |
| SCHEMBL6090867 | 0.72 | PDPK1 (0.45) | KDRPDGFRBPDPK1RETFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1218373-A2 | 2-PYRAZOLIN-5-ONES AS TYROSINE KINASE INHIBITORS | BASF AKTIENGESELLSCHAFT (DE) | 2002-07-03 | — | — | EP | claimed |
| WO-2001009121-A2 | 2-PYRAZOLIN-5-ONES_AS TYROSINE KINASE INHIBITORS | BASF AKTIENGESELLSCHAFT (DE) | 2001-02-08 | — | — | WO | claimed |
| US-7060822-B1 | 2-pyrazolin-5-ones | ABBOTT GMBH & CO. KG (DE) | 2006-06-13 | — | — | US | disclosed |
| EP-1218373-A2 | 2-PYRAZOLIN-5-ONES AS TYROSINE KINASE INHIBITORS | BASF AKTIENGESELLSCHAFT (DE) | 2002-07-03 | — | — | EP | disclosed |
| WO-2001009121-A2 | 2-PYRAZOLIN-5-ONES_AS TYROSINE KINASE INHIBITORS | BASF AKTIENGESELLSCHAFT (DE) | 2001-02-08 | — | — | WO | disclosed |