Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6092439 | 1.00 | PDPK1 (0.44) | PDPK1NPC1POLBMAPTRAB9A | |
| SCHEMBL6087800 | 0.83 | PDPK1 (0.40) | PDPK1NPC1MAPTKMT2A | |
| SCHEMBL6087797 | 0.83 | PDPK1 (0.40) | PDPK1NPC1MAPTKMT2A | |
| SCHEMBL6091115 | 0.80 | — | — | |
| SCHEMBL6089027 | 0.79 | PDE3B (0.34) | — | |
| SCHEMBL6089031 | 0.79 | PDE3B (0.34) | — | |
| SCHEMBL6091402 | 0.78 | KDR (0.38) | NPC1POLBMAPTRAB9AKMT2A | |
| SCHEMBL6091408 | 0.78 | KDR (0.38) | NPC1POLBMAPTRAB9AKMT2A | |
| SCHEMBL6090176 | 0.76 | KDR (0.39) | NPC1POLBMAPTRAB9AKMT2A | |
| SCHEMBL6090170 | 0.76 | KDR (0.39) | NPC1POLBMAPTRAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1218373-A2 | 2-PYRAZOLIN-5-ONES AS TYROSINE KINASE INHIBITORS | BASF AKTIENGESELLSCHAFT (DE) | 2002-07-03 | — | — | EP | claimed |
| WO-2001009121-A2 | 2-PYRAZOLIN-5-ONES_AS TYROSINE KINASE INHIBITORS | BASF AKTIENGESELLSCHAFT (DE) | 2001-02-08 | — | — | WO | claimed |
| US-7060822-B1 | 2-pyrazolin-5-ones | ABBOTT GMBH & CO. KG (DE) | 2006-06-13 | — | — | US | disclosed |
| EP-1218373-A2 | 2-PYRAZOLIN-5-ONES AS TYROSINE KINASE INHIBITORS | BASF AKTIENGESELLSCHAFT (DE) | 2002-07-03 | — | — | EP | disclosed |
| WO-2001009121-A2 | 2-PYRAZOLIN-5-ONES_AS TYROSINE KINASE INHIBITORS | BASF AKTIENGESELLSCHAFT (DE) | 2001-02-08 | — | — | WO | disclosed |