Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMGCR | P04035 | 16/20 | 0.83 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.51 |
| ▸ | SIRT6 | Q8N6T7 | 2/20 | 0.51 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.51 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.51 |
| ▸ | PGR | P06401 | 1/20 | 0.51 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.51 |
| ▸ | RXRA | P19793 | 1/20 | 0.51 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.51 |
| ▸ | CCKAR | P32238 | 1/20 | 0.51 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.51 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.51 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.51 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.51 |
| ▸ | SLC10A1 | Q14973 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6091667 | 0.99 | HMGCR (0.82) | HMGCRCYP2C9SIRT6ABCC3ABCB11 | |
| SCHEMBL6091006 | 0.98 | HMGCR (0.85) | HMGCRCYP2C9SIRT6ABCC3ABCB11 | |
| SCHEMBL6090635 | 0.97 | HMGCR (0.88) | HMGCRCYP2C9SIRT6ABCC3ABCB11 | |
| SCHEMBL6091375 | 0.96 | HMGCR (0.87) | HMGCRCYP2C9SIRT6ABCC3ABCB11 | |
| SCHEMBL6093156 | 0.96 | HMGCR (0.87) | HMGCRCYP2C9SIRT6ABCC3ABCB11 | |
| SCHEMBL6091668 | 0.93 | HMGCR (0.95) | HMGCR | |
| SCHEMBL6091600 | 0.92 | HMGCR (0.88) | HMGCRCYP2C9SIRT6ABCC3ABCB11 | |
| SCHEMBL6091498 | 0.91 | HMGCR (0.86) | HMGCRCYP2C9SIRT6ABCC3ABCB11 | |
| SCHEMBL6091512 | 0.91 | HMGCR (0.86) | HMGCRCYP2C9SIRT6ABCC3ABCB11 | |
| SCHEMBL6093100 | 0.90 | HMGCR (0.87) | HMGCRCYP2C9SIRT6ABCC3ABCB11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006059210-A2 | FUSED BICYCLIC PYRROLS AS HMG-COA REDUCTASE INHIBITORS | WARNER-LAMBERT COMPANY LLC (US) | 2006-06-08 | — | — | WO | claimed |
| WO-2006059210-A2 | FUSED BICYCLIC PYRROLS AS HMG-COA REDUCTASE INHIBITORS | WARNER-LAMBERT COMPANY LLC (US) | 2006-06-08 | — | — | WO | disclosed |