Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 10/20 | 0.41 |
| ▸ | PRKCB | P05771 | 7/20 | 0.41 |
| ▸ | PRKCA | P17252 | 4/20 | 0.39 |
| ▸ | CNR2 | P34972 | 4/20 | 0.38 |
| ▸ | CNR1 | P21554 | 3/20 | 0.38 |
| ▸ | ELANE | P08246 | 1/20 | 0.38 |
| ▸ | PRKCG | P05129 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | KDR | P35968 | 2/20 | 0.35 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.35 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.35 |
| ▸ | NTRK3 | Q16288 | 2/20 | 0.35 |
| ▸ | NTRK2 | Q16620 | 2/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | AURKA | O14965 | 1/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.35 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6092994 | 1.00 | GSK3B (0.41) | GSK3BPRKCBPRKCACNR2CNR1 | |
| SCHEMBL7495751 | 0.78 | CCNB2 (0.34) | ELANEMAPTKDRMEN1CDK1 | |
| SCHEMBL6092457 | 0.77 | GSK3B (0.49) | GSK3BPRKCBPRKCACNR2CNR1 | |
| SCHEMBL6092462 | 0.77 | GSK3B (0.49) | GSK3BPRKCBPRKCACNR2CNR1 | |
| SCHEMBL6090488 | 0.75 | CHEK1 (0.50) | PRKCBELANECHEK2CDK1RET | |
| SCHEMBL6090482 | 0.75 | CHEK1 (0.50) | PRKCBELANECHEK2CDK1RET | |
| SCHEMBL6090622 | 0.75 | GSK3B (0.44) | GSK3BPRKCBPRKCACNR2CNR1 | |
| SCHEMBL6090619 | 0.75 | GSK3B (0.44) | GSK3BPRKCBPRKCACNR2CNR1 | |
| SCHEMBL6089036 | 0.74 | GSK3B (0.42) | GSK3BPRKCBPRKCACNR2CNR1 | |
| SCHEMBL6089028 | 0.74 | GSK3B (0.42) | GSK3BPRKCBPRKCACNR2CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7060822-B1 | 2-pyrazolin-5-ones | ABBOTT GMBH & CO. KG (DE) | 2006-06-13 | — | — | US | disclosed |