Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 11/20 | 0.48 |
| ▸ | FGFR1 | P11362 | 5/20 | 0.48 |
| ▸ | PDGFRB | P09619 | 4/20 | 0.48 |
| ▸ | CHEK1 | O14757 | 4/20 | 0.40 |
| ▸ | CSF1R | P07333 | 4/20 | 0.34 |
| ▸ | RET | P07949 | 3/20 | 0.34 |
| ▸ | FLT1 | P17948 | 3/20 | 0.34 |
| ▸ | LCK | P06239 | 2/20 | 0.34 |
| ▸ | PHKG2 | P15735 | 2/20 | 0.34 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.34 |
| ▸ | AXL | P30530 | 2/20 | 0.34 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | FYN | P06241 | 1/20 | 0.34 |
| ▸ | KIT | P10721 | 1/20 | 0.34 |
| ▸ | ABL2 | P42684 | 1/20 | 0.34 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.34 |
| ▸ | AURKA | O14965 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6093552 | 1.00 | KDR (0.48) | KDRFGFR1PDGFRBCHEK1CSF1R | |
| SCHEMBL6091540 | 0.93 | KDR (0.41) | KDRFGFR1PDGFRBCHEK1CSF1R | |
| SCHEMBL6091544 | 0.93 | KDR (0.41) | KDRFGFR1PDGFRBCHEK1CSF1R | |
| SCHEMBL6091062 | 0.92 | KDR (0.41) | KDRFGFR1PDGFRBCHEK1CSF1R | |
| SCHEMBL6091067 | 0.92 | KDR (0.41) | KDRFGFR1PDGFRBCHEK1CSF1R | |
| SCHEMBL6091298 | 0.83 | KDR (0.48) | KDRFGFR1PDGFRBCHEK1CSF1R | |
| SCHEMBL6091302 | 0.83 | KDR (0.48) | KDRFGFR1PDGFRBCHEK1CSF1R | |
| SCHEMBL6090614 | 0.83 | KDR (0.49) | KDRFGFR1PDGFRBCHEK1CSF1R | |
| SCHEMBL6090621 | 0.83 | KDR (0.49) | KDRFGFR1PDGFRBCHEK1CSF1R | |
| SCHEMBL6090179 | 0.82 | SRC (0.45) | KDRFGFR1PDGFRBLCKFYN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7060822-B1 | 2-pyrazolin-5-ones | ABBOTT GMBH & CO. KG (DE) | 2006-06-13 | — | — | US | disclosed |