Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 20/20 | 0.70 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.70 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.70 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.70 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.70 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6094830 | 1.00 | IGF1R (0.70) | IGF1RCYP3A4CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL6095577 | 0.84 | IGF1R (0.84) | IGF1RCYP3A4CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL5517812 | 0.84 | IGF1R (0.84) | IGF1RCYP3A4CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL6096072 | 0.83 | IGF1R (0.66) | IGF1RCYP3A4CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL6096069 | 0.83 | IGF1R (0.66) | IGF1RCYP3A4CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL5136817 | 0.82 | IGF1R (1.00) | IGF1RCYP3A4CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL5136815 | 0.82 | IGF1R (1.00) | IGF1RCYP3A4CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL5137613 | 0.82 | IGF1R (1.00) | IGF1RCYP3A4CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL5136190 | 0.82 | IGF1R (1.00) | IGF1RCYP3A4CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL5136186 | 0.82 | IGF1R (1.00) | IGF1RCYP3A4CYP1A2CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7081454-B2 | Tyrosine kinase inhibitors | BRISTOL-MYERS SQUIBB CO. (US) | 2006-07-25 | — | — | US | disclosed |