Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JUN | P05412 | 3/20 | 0.54 |
| ▸ | FOS | P01100 | 2/20 | 0.54 |
| ▸ | GSK3B | P49841 | 7/20 | 0.44 |
| ▸ | BACE1 | P56817 | 6/20 | 0.44 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.44 |
| ▸ | DAO | P14920 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.37 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | MGAM | O43451 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | SI | P14410 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1463002 | 0.81 | HCAR2 (0.47) | BACE1DAOHDAC1HDAC2HDAC8 | |
| SCHEMBL1463003 | 0.81 | HCAR2 (0.47) | BACE1DAOHDAC1HDAC2HDAC8 | |
| SCHEMBL13305777 | 0.78 | DAO (0.42) | DAOHCAR2NPC1RAB9ATP53 | |
| SCHEMBL8948187 | 0.78 | DAO (0.42) | DAOHCAR2NPC1RAB9ATP53 | |
| SCHEMBL20586110 | 0.77 | CYP1A2 (0.41) | JUNFOSGSK3BBACE1TLR9 | |
| SCHEMBL8987306 | 0.76 | MAPT (0.55) | NPC1RAB9ASMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL18639716 | 0.72 | DAO (0.38) | DAOHDAC1HDAC2HDAC8HCAR2 | |
| SCHEMBL18874102 | 0.72 | DAO (0.39) | DAO | |
| SCHEMBL12644866 | 0.71 | TTR (0.48) | HCAR2NPC1RAB9AKDM4EMAPT | |
| SCHEMBL28984309 | 0.71 | TNFRSF1A (0.43) | KDM4EALDH1A1TNFRSF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120040976-A1 | SMALL MOLECULE IMMUNOMODULATORS FOR ALZHEIMER'S DISEASE | HUMAN BIOMOLECULAR RESEARCH INSTITUTE (US) | 2012-02-16 | — | — | US | disclosed |
| WO-2010068935-A2 | SMALL MOLECULE IMMUNOMODULATORS FOR ALZHEIMER'S DISEASE | HUMAN BIOMOLECULAR RESEARCH INSTITUTE (US) | 2010-06-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120040976-A1 | SMALL MOLECULE IMMUNOMODULATORS FOR ALZHEIMER'S DISEASE | L1CAM, LY96, GMFG | JUN 4222/4885FOS 4116/4885GSK3B 3394/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.