Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | SIRT6 | Q8N6T7 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5653005 | 0.85 | MAPT (0.47) | MAPTHRH3ALDH1A1MAPK1SIRT6 | |
| SCHEMBL1092846 | 0.85 | MAPT (0.47) | MAPTHRH3ALDH1A1MAPK1SIRT6 | |
| SCHEMBL223024 | 0.85 | MAPT (0.47) | MAPTHRH3ALDH1A1MAPK1SIRT6 | |
| SCHEMBL13292851 | 0.85 | KMT2A (0.50) | MAPTHRH3ALDH1A1MAPK1SIRT6 | |
| SCHEMBL12006068 | 0.83 | MAPT (0.49) | MAPTHRH3ALDH1A1MAPK1LMNA | |
| SCHEMBL2886399 | 0.83 | MAPT (0.49) | MAPTHRH3ALDH1A1MAPK1LMNA | |
| SCHEMBL12006634 | 0.82 | MAPT (0.46) | MAPTHRH3ALDH1A1MAPK1SIRT6 | |
| SCHEMBL791700 | 0.82 | MAPT (0.46) | MAPTHRH3ALDH1A1MAPK1SIRT6 | |
| SCHEMBL12006635 | 0.82 | MAPT (0.46) | MAPTHRH3ALDH1A1MAPK1SIRT6 | |
| SCHEMBL6712874 | 0.82 | MAPT (0.44) | MAPTHRH3ALDH1A1MAPK1SIRT6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7132543-B2 | Para-phenylenediamine derivatives containing a disubstituted pyrrolidinyl group bearing a cationic radical, and use of the same for dyeing keratin fibers | L'OREAL S.A. (FR) | 2006-11-07 | — | — | US | disclosed |
| US-20040248961-A1 | Para-phenylenediamine derivatives containing a disubstituted pyrrolidinyl group bearing a cationic radical, and use of the same for dyeing keratin fibers | L'OREAL S.A. (FR) | 2004-12-09 | — | — | US | disclosed |
| EP-1462453-A1 | Paraphenylenediamin derivatives comprising a substituted pyrrolidinyl group and bearing a cationic radical as well as their use for dyeing keratinic fibres | L'OREAL (FR) | 2004-09-29 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040248961-A1 | Para-phenylenediamine derivatives containing a disubstituted pyrrolidinyl group bearing a cationic radical, and use of the same for dyeing keratin fibers | KRT18, CDC73, PKN1 | MAPT 2722/4885HRH3 2090/4885ALDH1A1 783/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.