Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTK2 | Q05397 | 3/20 | 0.85 |
| ▸ | AURKA | O14965 | 2/20 | 0.85 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.85 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.85 |
| ▸ | IGF1R | P08069 | 19/20 | 0.84 |
| ▸ | CYP3A4 | P08684 | 16/20 | 0.84 |
| ▸ | EGFR | P00533 | 2/20 | 0.84 |
| ▸ | INSR | P06213 | 2/20 | 0.84 |
| ▸ | LCK | P06239 | 2/20 | 0.84 |
| ▸ | KDR | P35968 | 2/20 | 0.84 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.84 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.84 |
| ▸ | MET | P08581 | 1/20 | 0.84 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.84 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.84 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.84 |
| ▸ | PLK4 | O00444 | 1/20 | 0.84 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.84 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.84 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.84 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4145381 | 0.93 | IGF1R (0.84) | PTK2AURKAAURKBALKIGF1R | |
| SCHEMBL4132576 | 0.91 | IGF1R (1.00) | PTK2AURKAAURKBALKIGF1R | |
| SCHEMBL30540378 | 0.91 | IGF1R (1.00) | PTK2AURKAAURKBALKIGF1R | |
| SCHEMBL30540371 | 0.91 | IGF1R (1.00) | PTK2AURKAAURKBALKIGF1R | |
| SCHEMBL4132577 | 0.91 | IGF1R (1.00) | PTK2AURKAAURKBALKIGF1R | |
| SCHEMBL4131143 | 0.91 | IGF1R (0.85) | PTK2AURKAAURKBALKIGF1R | |
| SCHEMBL5517921 | 0.90 | IGF1R (0.86) | PTK2AURKAAURKBALKIGF1R | |
| SCHEMBL4004304 | 0.90 | IGF1R (0.86) | PTK2AURKAAURKBALKIGF1R | |
| SCHEMBL14510505 | 0.88 | IGF1R (0.85) | PTK2AURKAAURKBALKIGF1R | |
| SCHEMBL5135881 | 0.87 | PTK2 (0.76) | PTK2AURKAAURKBALKIGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7081454-B2 | Tyrosine kinase inhibitors | BRISTOL-MYERS SQUIBB CO. (US) | 2006-07-25 | — | — | US | claimed |
| US-7223757-B2 | Tyrosine kinase inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-05-29 | — | — | US | disclosed |
| US-7223757-B2 | Tyrosine kinase inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-05-29 | — | — | US | disclosed |
| US-7081454-B2 | Tyrosine kinase inhibitors | BRISTOL-MYERS SQUIBB CO. (US) | 2006-07-25 | — | — | US | disclosed |