Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 20/20 | 0.67 |
| ▸ | CYP3A4 | P08684 | 8/20 | 0.63 |
| ▸ | CYP1A2 | P05177 | 7/20 | 0.63 |
| ▸ | CYP2C9 | P11712 | 7/20 | 0.63 |
| ▸ | CYP2C19 | P33261 | 7/20 | 0.63 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6096452 | 1.00 | IGF1R (0.67) | IGF1RCYP3A4CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL5135629 | 0.90 | IGF1R (0.79) | IGF1RCYP3A4CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL5135627 | 0.90 | IGF1R (0.79) | IGF1RCYP3A4CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL6096682 | 0.87 | IGF1R (0.68) | IGF1RCYP3A4CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL6096652 | 0.87 | IGF1R (0.68) | IGF1RCYP3A4CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL6095273 | 0.87 | IGF1R (0.69) | IGF1RCYP3A4CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL6095304 | 0.87 | IGF1R (0.69) | IGF1RCYP3A4CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL6095354 | 0.86 | IGF1R (0.61) | IGF1RCYP3A4CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL6095323 | 0.86 | IGF1R (0.61) | IGF1RCYP3A4CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL5137939 | 0.86 | IGF1R (0.76) | IGF1RCYP3A4CYP1A2CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7081454-B2 | Tyrosine kinase inhibitors | BRISTOL-MYERS SQUIBB CO. (US) | 2006-07-25 | — | — | US | disclosed |