SCHEMBL6097249

SCHEMBL6097249

[O-][S+]1NC=CC=c2ccc3c(c21)C=CN=3

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3122958 0.68
SCHEMBL6210725 0.67
SCHEMBL2050390 0.55
SCHEMBL11985519 0.53
SCHEMBL6645893 0.52
SCHEMBL5199243 0.52
SCHEMBL18765996 0.52
SCHEMBL3641984 0.52
SCHEMBL332957 0.52
SCHEMBL16913025 0.52

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7078521-B2 Process for the preparation of 9-amino substituted 9,10-dihydropyrrolo[2,1-b][1,3]benzotiazepines SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) 2006-07-18 US claimed
EP-1305318-B1 PROCESS FOR THE PREPARATION OF 9-AMINO SUBSTITUTED 9,10-DIHYDROPYRROLO [2,1-B] [1,3]BENZOTHIAZEPINES SIGMA TAU IND FARMACEUTI (IT) 2004-03-17 EP claimed
US-20030181437-A1 Process for the preparation of 9-amino substituted 9,10-dihydropyrrolo[2,1-B][1,3]benzotiazepines SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A (IT) 2003-09-25 US claimed
EP-1305318-A1 PROCESS FOR THE PREPARATION OF 9-AMINO SUBSTITUTED 9,10-DIHYDROPYRROLO 2,1-B] 1,3]BENZOTIAZEPINES Sigma-Tau Industrie Farmaceutiche Riunite S.p.A. (IT) 2003-05-02 EP claimed
EP-1100803-B1 PYRROLO [2,1-B] [1,3]BENZOTHIAZEPINES WITH ATYPICAL ANTIPSYCHOTIC ACTIVITY SIGMA TAU IND FARMACEUTI (IT) 2002-10-02 EP claimed
US-6391870-B2 DOPAMINERGIC AGENT SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) 2002-05-21 US claimed
WO-2002010174-A1 PROCESS FOR THE PREPARATION OF 9-AMINO SUBSTITUTED 9,10-DIHYDROPYRROLO [2,1-B][1,3]BENZOTIAZEPINES SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) 2002-02-07 WO claimed
US-20020006921-A1 Pyrrolo {2,1-b}{1,3}benzothiazepines with atypical antipsychotic activity SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) 2002-01-17 US claimed
EP-1100803-A2 PYRROLO 2,1-B] 1,3]BENZOTHIAZEPINES WITH ATYPICAL ANTIPSYCHOTIC ACTIVITY Sigma-Tau Industrie Farmaceutiche Riunite S.p.A. (IT) 2001-05-23 EP claimed
WO-2000006579-A2 PYRROLO[2,1-B][1,3]BENZOTHIAZEPINES WITH ATYPICAL ANTIPSYCHOTIC ACTIVITY SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) 2000-02-10 WO claimed
US-7078521-B2 Process for the preparation of 9-amino substituted 9,10-dihydropyrrolo[2,1-b][1,3]benzotiazepines SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) 2006-07-18 US disclosed
US-6806267-B1 ANTITUMOUR AGENTS; OVERCOMING CHRONIC MYELOID LEUKEMIA ASSOCIATED DRUG RESISTANCE; SUCH AS 4-ACETOXY-5-PHENYL-NAPHTO(2,3-B)PYRROLO(1,2-D)(1,4)OXAZEPINE THE UNIVERSITA'DI SIENA (IT) 2004-10-19 US disclosed
EP-1305318-B1 PROCESS FOR THE PREPARATION OF 9-AMINO SUBSTITUTED 9,10-DIHYDROPYRROLO [2,1-B] [1,3]BENZOTHIAZEPINES SIGMA TAU IND FARMACEUTI (IT) 2004-03-17 EP disclosed
US-20030181437-A1 Process for the preparation of 9-amino substituted 9,10-dihydropyrrolo[2,1-B][1,3]benzotiazepines SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A (IT) 2003-09-25 US disclosed
EP-1305318-A1 PROCESS FOR THE PREPARATION OF 9-AMINO SUBSTITUTED 9,10-DIHYDROPYRROLO 2,1-B] 1,3]BENZOTIAZEPINES Sigma-Tau Industrie Farmaceutiche Riunite S.p.A. (IT) 2003-05-02 EP disclosed
US-20020006921-A1 Pyrrolo {2,1-b}{1,3}benzothiazepines with atypical antipsychotic activity SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) 2002-01-17 US disclosed
WO-2001058904-A1 APOPTOSIS-INDUCING COMPOUNDS THE PROVOST, FELLOWS AND SCHOLARS OF THE COLLEGE OF THE HOLY AND UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN (IE) 2001-08-16 WO disclosed
EP-1100803-A2 PYRROLO 2,1-B] 1,3]BENZOTHIAZEPINES WITH ATYPICAL ANTIPSYCHOTIC ACTIVITY Sigma-Tau Industrie Farmaceutiche Riunite S.p.A. (IT) 2001-05-23 EP disclosed
WO-2000006579-A2 PYRROLO[2,1-B][1,3]BENZOTHIAZEPINES WITH ATYPICAL ANTIPSYCHOTIC ACTIVITY SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) 2000-02-10 WO disclosed
WO-1999056736-A2 APOPTOSIS-INDUCING COMPOUNDS THE PROVOST, FELLOWS AND SCHOLARS OF THE COLLEGE OF THE HOLY AND UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN (IE) 1999-11-11 WO disclosed